Antibody Expression and Production
by Al-Rubeai, MohamedEdition: 1st
Format: Hardcover
Pub. Date: 2011-05-20
Publisher(s): Springer Verlag
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Summary
Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.
Table of Contents
| Expression of Antibody, in Mammalian Cells | p. 1 |
| Bioreactor Systems for Producing Antibody from Mammalian Cells | p. 25 |
| Production of Antibody in Insect Cells | p. 53 |
| Production of Monoclonal Antibodies in Glycoengineered Pichia pastoris | p. 77 |
| Production of Antibodies in Hansenula polymorpha | p. 99 |
| Production of Antibody by Transgenic Avians | p. 121 |
| Production of Antibodies in Plants | p. 143 |
| Production of Antibody Fab Fragments in Escherichia coli | p. 165 |
| Intrabody Expression in Mammalian Cells | p. 179 |
| Engineering Antibodies for Cancer Therapy | p. 197 |
| Recombinant Bispecific Antibodies for Cancer Therapy | p. 235 |
| The Role of Glycosylation in Therapeutic Antibodies | p. 251 |
| Quality Issues Arising from Post-translational Modification of Recombinant Antibodies | p. 293 |
| Recovery and Purification of Antibody | p. 305 |
| Subject Index | p. 341 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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