Bioradicals Detected by Esr Spectroscopy

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Format: Hardcover
Pub. Date: 1995-11-01
Publisher(s): Birkhauser
List Price: $99.00

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Summary

This book presents the historical background as well as the up-to-date developments in, and guidelines for, bioradicals and ESR research.
Bioradicals Detected by ESR Spectroscopy is a newly coined term which encompasses paramagnetic species in biological systems, such as active oxygen radicals and transition metal ions. Research on the structures and functions of bioradicals have been attracting growing attention in the biological sciences, resulting in an increasing demand for comprehensive studies which allow researchers from many fields to understand the true importance of these species.
ESR spectroscopy is of great interest to interdisciplinary research and is applied in many fields, ranging from physics and chemistry to biology and medicine. New ESR technologies of multiquantum ESR, STM-ESR and open-space ESR, several ESR imaging techniques, spin trapping and new methods in in vivo spin trapping are all described and discussed in this volume. In addition, it demonstrates the applications of ESR in food and medical sciences, i.e., the estimation and characterization of the antioxidant ability of foods and food components and the elucidation of the underlying chemical mechanisms.

Table of Contents

Preface
Overview of bioradicals and ESR technologyp. 1
Chemistry of oxygen radicalsp. 17
Multiquantum ESR: Physics, technology and applications to bioradicalsp. 31
Scanning tunneling microscopy (STM) methods for detecting ESR of a single spin centerp. 49
An open space ESR spectrometer and its application to high dielectric loss samplesp. 63
New experimental modalities of low frequency electron paramagnetic resonance imagingp. 69
Whole body electron spin resonance imaging spectrometerp. 93
Development of the rapid field scan L-band ESR-CT systemp. 103
Spin trappingp. 113
History of spin trapping in Japanp. 143
In vivo ESR observation bioradical metabolites in living animalsp. 155
Dithiocarbamate spin traps for in vivo detection of nitric oxide production in micep. 163
Recent developments in spin labelingp. 173
Electron spin resonance imaging of rat brainp. 193
ESEEM spectroscopy - probing active site structures of metalloproteinsp. 203
Nitric oxide, a versatile biological ligand for hemeproteinsp. 217
Vitamin E and antioxidant interactions in biological systemsp. 237
Antioxidant activity of vitamin E and vitamin C derivatives in membrane mimetic systemsp. 259
Action of antioxidant as studied by electron spin resonancep. 277
In vivo EPR spectroscopyp. 285
Pharmaceutical aspects of ESR investigation on drug delivery systems, tissues and living systemsp. 301
In vivo ESR measurement of free radical reactions in living animals using nitroxyl probesp. 321
Subject Indexp. 325
Table of Contents provided by Blackwell. All Rights Reserved.

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