
Bioradicals Detected by Esr Spectroscopy
by Ohya-Nishiguchi, H.; Packer, L.Buy New
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Summary
Bioradicals Detected by ESR Spectroscopy is a newly coined term which encompasses paramagnetic species in biological systems, such as active oxygen radicals and transition metal ions. Research on the structures and functions of bioradicals have been attracting growing attention in the biological sciences, resulting in an increasing demand for comprehensive studies which allow researchers from many fields to understand the true importance of these species.
ESR spectroscopy is of great interest to interdisciplinary research and is applied in many fields, ranging from physics and chemistry to biology and medicine. New ESR technologies of multiquantum ESR, STM-ESR and open-space ESR, several ESR imaging techniques, spin trapping and new methods in in vivo spin trapping are all described and discussed in this volume. In addition, it demonstrates the applications of ESR in food and medical sciences, i.e., the estimation and characterization of the antioxidant ability of foods and food components and the elucidation of the underlying chemical mechanisms.
Table of Contents
Preface | |
Overview of bioradicals and ESR technology | p. 1 |
Chemistry of oxygen radicals | p. 17 |
Multiquantum ESR: Physics, technology and applications to bioradicals | p. 31 |
Scanning tunneling microscopy (STM) methods for detecting ESR of a single spin center | p. 49 |
An open space ESR spectrometer and its application to high dielectric loss samples | p. 63 |
New experimental modalities of low frequency electron paramagnetic resonance imaging | p. 69 |
Whole body electron spin resonance imaging spectrometer | p. 93 |
Development of the rapid field scan L-band ESR-CT system | p. 103 |
Spin trapping | p. 113 |
History of spin trapping in Japan | p. 143 |
In vivo ESR observation bioradical metabolites in living animals | p. 155 |
Dithiocarbamate spin traps for in vivo detection of nitric oxide production in mice | p. 163 |
Recent developments in spin labeling | p. 173 |
Electron spin resonance imaging of rat brain | p. 193 |
ESEEM spectroscopy - probing active site structures of metalloproteins | p. 203 |
Nitric oxide, a versatile biological ligand for hemeproteins | p. 217 |
Vitamin E and antioxidant interactions in biological systems | p. 237 |
Antioxidant activity of vitamin E and vitamin C derivatives in membrane mimetic systems | p. 259 |
Action of antioxidant as studied by electron spin resonance | p. 277 |
In vivo EPR spectroscopy | p. 285 |
Pharmaceutical aspects of ESR investigation on drug delivery systems, tissues and living systems | p. 301 |
In vivo ESR measurement of free radical reactions in living animals using nitroxyl probes | p. 321 |
Subject Index | p. 325 |
Table of Contents provided by Blackwell. All Rights Reserved. |
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