Cancer Bioinformatics : From Therapy Design to Treatment,9780470863053

Cancer Bioinformatics : From Therapy Design to Treatment

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ISBN13: 9780470863053
ISBN10: 0470863056
Format: eBook
Pub. Date: 2011-06-01
Publisher(s): Wiley
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Summary

"The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book." Dieter Naf, Jackson Laboratory, USA Cancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences. This groundbreaking title provides a comprehensive and up-to-date account of the enormous range of bioinformatics for cancer therapy development from the laboratory to clinical trials. It functions as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the interdisciplinary research community involved.

Table of Contents

Preface
List of Contributors
Cancer Systems
A Path to Knowledge: from Data to Complex Systems Models of Cancer
Conceptual foundations: biological complexity
A taxonomy of cancer complexity
Modelling and simulation of cancer systems
Data standards and integration
Concluding remarks
Theory of Cancer Robustness
Robustness: the fundamental organizational principle of biological systems
Underlying mechanisms for robustness
Intrinsic features of robust systems: evolvability and trade-offs
Cancer as a robust system
Therapy strategies
A proper index of treatment efficacy
Computational tools
Conclusion
Developing an Integrated Informatics Platform for Cancer Research
Background
The challenge
The UK National Cancer Research Institute (NCRI) informatics platform
Developing the informatics platform
Benefits of the platform
Conclusions
In silico Models
Mathematical Models of Cancer
Growth models
A very brief tour of cellular automata
Angiogenesis models
Treatment response models
Dynamic pathways models
Other models
Simulations of complex biological systems
Concluding remarks
Some Mathematical Modelling Challenges and Approaches in Cancer
Introduction
Multiscale modelling
Tumour vascular modelling
Population models
Conclusion
Computer Simulation of Tumour Response to Therapy
Introduction
Tumour growth simulation
Radiotherapy response simulation
Chemotherapy response simulation
Simulation of tumour response to other therapeutic modalities
Simulation of normal tissue response to antineoplastic interventions
Integration of molecular networks into tumour behaviour simulations
Future directions
Structural Bioinformatics in Cancer
Introduction
Macromolecular crystallography
Molecular modelling
Conclusions
In vivo Models
The Mouse Tumour Biology Database: an Online Resource for Mouse Models of Human Cancer
Introduction
Background
Database content
Data acquisition
Using the MTB database
Connecting the MTB database with related databases
Summary
Bioinformatics Approaches to Integrate Cancer Models and Human Cancer Research
Background
The MMHCC Informatics at the outset of the programme
Initial NCI bioinformatics infrastructure development
Future directions for informatics support
Summary
Data
The FAPESP/LICR Human Cancer Genome Project: Perspectives on Integration
Introduction
The FAPESP/LICR Human Cancer Genome Project
An integrated view of the tumour transcriptome
Summary
Today's Science, Tomorrow's Patient: the Pivotal Role of Tissue, Clinical Data and Informatics in Modern Drug Development
Introduction
A new national strategy for the provision of tissue annotated with clinical information to meet current and future needs of academic researchers and industry
The NCRI National Cancer Tissue Resource for cancer biology and treatment development
A potential future world-class resource integrating research and health service information systems and bioinformatics for cancer diagnosis and treatment
A proposed information system architecture that will meet the challenges and deliver the required functionality: an overview
Consent and confidentiality: ensuring that the NCTR is embedded in the UK's legal and ethical framework
Concluding remarks: future challenges and opportunities
Ethics
Software Design Ethics for Biomedicine
The problem: software and research
Risk identification
Biomedical software example
Is an ethical risk analysis required?
Details of SoDIS
A SoDIS analysis of the biomedical software example
Conclusion
Ethical Issues of Electronic Patient Data and Informatics in Clinical Trial Settings
Introduction
Ethical aspects of using patient-identifiable health data
Legislation and policies pertaining to patient-identifiable health data
Using anonymized and pseudonymized data
Protecting personal health data
Pharmacogenomics and Cancer: Ethical, Legal and Social Issues
Introduction
Getting pharmacogenomic tests and drugs to market
Cost and coverage issues
Ethical challenges of pharmacogenomics
Conclusion
Index
Table of Contents provided by Publisher. All Rights Reserved.

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