Cytochrome P450: Structure, Mechanism, and Biochemistry
by De Montellano, Paul R. OrtizEdition: 2nd
Format: Paperback
Pub. Date: 2010-12-01
Publisher(s): SPRINGER
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Summary
The Second Edition reviews the impressive progress that has been made in the last ten years in cytochrome P450 research. Chapters emphasize structure, mechanism, biochemistry, and regulation. This edition offers expanded coverage of P450 crystal structures, site-specific mutagenesis as a probe of structure and function. New chapters explore the hormonal regulation of P450 enzymes, the cytochrome P450-catalyzed oxidation of eicosanoids, human P450 enzymes, and thiolate-ligated hemoproteins other than P450.
Table of Contents
| Model Systems | |
| Models and Mechanisms of Cytochrome P450 Action | p. 3 |
| Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450 | p. 49 |
| Structurally Defined Bacterial Enzymes | |
| Twenty-five Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis | p. 83 |
| Structural Studies on Prokaryotic Cytochromes P450 | p. 125 |
| Bacterial P450s: Structural Similarities and Functional Differences | p. 151 |
| Structures and Mechanisms of Membrane-Bound P450 Enzymes | |
| Structures of Eukaryotic Cytochrome P450 Enzymes | p. 183 |
| NADPH Cytochrome P450 Reductase and Its Structural and Functional Domains | p. 225 |
| Oxygen Activation and Reactivity | p. 245 |
| Inhibition of Cytochrome P450 Enzymes | p. 305 |
| Regulatory Mechanisms and Physiological Roles of Cytochrome P450 | |
| Induction of Cytochrome P450 Enzymes that Metabolize Xenobiotics | p. 367 |
| Hormonal Regulation of Liver Cytochrome P450 Enzymes | p. 391 |
| Regulation of Steroidogenic and Related P450s | p. 419 |
| Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids | p. 443 |
| Human Cytochrome P450 Enzymes | p. 473 |
| Heme-Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenations | p. 537 |
| Appendices | |
| Cytochrome P450 Nomenclature and Alignment of Selected Sequences | p. 575 |
| Rat and Human Liver Cytochromes P450: Substrate and Inhibitor Specificities and Functional Markers | p. 607 |
| Index | p. 631 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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