Fundamentals and Applications of Microfluidics,9781580533430

Fundamentals and Applications of Microfluidics

by ;
ISBN13: 9781580533430
ISBN10: 1580533434
Format: Hardcover
Pub. Date: 2002-10-01
Publisher(s): Artech House
List Price: $99.00

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Summary

Look to this authoritative, new resource for a comprehensive introduction to the emerging field of microfluidics. The book shows you how to take advantage of the performance benefits of microfluidics and serves as your instant reference for state-of-the-art technology and applications in this cutting-edge area. It offers you practical guidance in choosing the best fabrication and enabling technology for a specific microfluidic application, and shows you how to design a microfluidic device.

Author Biography

Nam-Trung Nguyen is an assistant professor at the School of Mechanical and Production Engineering at Nanyang Technological University.

Table of Contents

Preface xi
Acknowledgments xiii
Introduction
1(10)
Microfluidics - The Emerging Technology
1(6)
What is Microfluidics?
1(3)
Commercial Aspects
4(2)
Scientific Aspects
6(1)
Milestones of Microfluidics
7(2)
Device Development
7(1)
Technology Development
8(1)
Organization of the Book
9(2)
References
10(1)
Fluid Mechanics Theory
11(56)
Introduction
11(9)
Intermolecular Forces
13(2)
The Three States of Matter
15(1)
Continuum Assumption
16(4)
Continuum Fluid Mechanics at Small Scales
20(27)
Gas Flows
21(6)
Liquid Flows
27(2)
Boundary Conditions
29(5)
Parallel Flows
34(6)
Low Reynolds Number Flows
40(2)
Entrance Effects
42(3)
Surface Tension
45(2)
Molecular Approaches
47(6)
MD
48(3)
DSMC Technique
51(2)
Electrokinetics
53(9)
Electro-Osmosis
54(3)
Electrophoresis
57(3)
Dielectrophoresis
60(2)
Conclusion
62(5)
Problems
64(1)
References
65(2)
Fabrication Techniques for Microfluidics
67(70)
Basic Microtechniques
67(15)
Photolithography
67(2)
Additive Techniques
69(9)
Subtractive Techniques
78(2)
Pattern Transfer Techniques
80(2)
Silicon-Based Micromachining Techniques
82(16)
Silicon Bulk Micromachining
82(8)
Silicon Surface Micromachining
90(8)
Polymer-Based Micromachining Techniques
98(20)
Thick Resist Lithography
98(6)
Polymeric Surface Micromachining
104(3)
Soft Lithography
107(5)
Microstereo Lithography
112(4)
Micromolding
116(2)
Other Micromachining Techniques
118(4)
Subtractive Techniques
118(3)
Additive Techniques
121(1)
Assembly and Packaging of Microfluidic Devices
122(5)
Wafer Level Assembly and Packaging
122(2)
Device Level Packaging
124(3)
Biocompatibility
127(10)
Material Response
128(1)
Tissue and Cellular Response
128(1)
Biocompatibility Tests
128(1)
Problems
129(1)
References
129(8)
Experimental Flow Characterization
137(70)
Introduction
137(7)
Pointwise Methods
138(1)
Full- Field Methods
138(6)
Overview of Micro-PIV
144(19)
Fundamental Physics Considerations of Micro-PIV
144(11)
Special Processing Methods for Micro-PIV Recordings
155(5)
Advanced Processing Methods Suitable for Both Micro/Macro-PIV Recordings
160(3)
Micro-PIV Examples
163(13)
Flow in a Microchannel
163(5)
Flow in a Micronozzle
168(3)
Flow Around a Blood Cell
171(2)
Flow in Microfluidic Biochip
173(2)
Conclusions
175(1)
Extensions of the Micro-PIV technique
176(31)
Microfluidic Nanoscope
176(7)
Microparticle Image Thermometry
183(12)
Infrared Micro-PIV
195(2)
Particle Tracking Velocimetry
197(4)
Problems
201(1)
References
201(6)
Microfluidics for External Flow Control
207(40)
Velocity and Turbulence Measurement
207(15)
Velocity Sensors
208(4)
Shear Stress Sensors
212(10)
Turbulence Control
222(4)
Microflaps
223(1)
Microballoon
224(1)
Microsynthetic Jet
225(1)
Microair Vehicles
226(21)
Fixed-Wing MAV
227(2)
Flapping-Wing MAV
229(3)
Microrotorcraft
232(2)
Microrockets
234(9)
Problems
243(2)
References
245(2)
Microfluidics for Internal Flow Control: Microvalves
247(46)
Design Considerations
250(4)
Actuators
250(2)
Valve Spring
252(1)
Valve Seat
253(1)
Pressure Compensation Design
253(1)
Pneumatic Valves
254(3)
Pneumatic Actuators
254(1)
Design Examples
255(2)
Thermopneumatic Valves
257(6)
Thermopneumatic Actuators
257(4)
Design Examples
261(2)
Thermomechanical Valves
263(8)
Solid-Expansion Valves
263(1)
Bimetallic Valves
264(4)
Shape-Memory Alloy Valves
268(3)
Piezoelectric Valves
271(4)
Piezoelectric Actuators
271(2)
Design Examples
273(2)
Electrostatic Valves
275(6)
Electrostatics Actuators
275(4)
Design Examples
279(2)
Electromagnetic Valves
281(2)
Electromagnetic Actuators
281(1)
Design Examples
281(2)
Electrochemical Valves
283(2)
Capillary-Force Valves
285(8)
Capillary-Force Actuators
285(3)
Design Examples
288(1)
Problems
289(1)
References
289(4)
Microfluidics for Internal Flow Control: Micropumps
293(50)
Mechanical Pumps
295(23)
Design Considerations
295(2)
Check-Valve Pumps
297(7)
Peristaltic Pumps
304(4)
Valveless Rectification Pumps
308(5)
Rotary Pumps
313(2)
Centrifugal Pumps
315(2)
Ultrasonic Pumps
317(1)
Nonmechanical Pumps
318(16)
Electrical Pumps
318(9)
Surface Tension Driven Pumps
327(4)
Chemical Pumps
331(1)
Magnetic Pumps
332(2)
Scaling Law for Micropumps
334(9)
Problems
336(1)
References
337(6)
Microfluidics for Internal Flow Control: Microflow Sensors
343(30)
Nonthermal Flow Sensors
345(9)
Differential Pressure Flow Sensors
345(4)
Drag Force Flow Sensors
349(3)
Life Force Flow Sensors
352(1)
Coriolis Flow Sensors
352(1)
Electrohydrodynamic Flow Sensors
353(1)
Thermal Flow Sensors
354(19)
Design Considerations
354(5)
Thermoresistive Flow Sensors
359(4)
Thermocapacitive Flow Sensors
363(1)
Thermoelectric Flow Sensors
364(1)
Thermoelectronic Flow Sensors
365(3)
Pyroelectric Flow Sensors
368(1)
Frequency Analog Sensors
369(1)
Problems
369(1)
References
370(3)
Microfluidics for Life Sciences and Chemistry
373(80)
Microfilters
373(6)
Design Considerations
374(2)
Design Examples
376(3)
Microneedles
379(7)
Design Considerations
380(3)
Design Examples
383(3)
Micromixers
386(15)
Design Considerations
389(5)
Design Examples
394(7)
Microreactors
401(22)
Design Considerations
403(1)
Design Examples
404(19)
Microdispensers
423(11)
Design Considerations
424(4)
Design Examples
428(6)
Microseparators
434(19)
Design Considerations
435(2)
Gas Chromatography
437(2)
Liquid Chromatography
439(1)
Electrophoresis
440(2)
Problems
442(3)
References
445(8)
Appendix A List of Symbols 453(4)
Appendix B Resources for Microfluidics Research 457(2)
Appendix C Abbreviations of Different Plastics 459(2)
Appendix D Linear Elastic Deflection Models 461(2)
About the Authors 463(1)
Index 465

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