Handbook of Cancer Vaccines,9781588292094

Handbook of Cancer Vaccines

by ; ;
Edition: CD
ISBN13: 9781588292094
ISBN10: 1588292096
Format: Hardcover
Pub. Date: 2004-01-01
Publisher(s): Humana Pr Inc
List Price: $279.99

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Summary

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Table of Contents

Acknowledgments v
Preface vii
Contributors xiii
Value-Added eBook/PDA xvii
PART I: BASIC SCIENCE OF TUMOR ANTIGENS AND IMMUNE ACTIVATION
1 Biology of the Cancer Vaccine Immune Response
3(8)
Michael A. Morse, Timothy M. Clay, and H. Kim Lyerly
2 The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity
11(8)
John Fikes
3 Identification of Tumor Antigens Using Subtraction and Microarrays
19(12)
Jiangchun Xu
4 Tumor Antigen Discovery With T Cells
31(18)
Paul F. Robbins
5 Targeting Viral Antigens for the Treatment of Malignancies
49(16)
Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau, Michael I. Nishimura, and W. Martin Kast
6 Immune Defects in Cancer
65(20)
Dmitry Gabrilovich and Vladimir Pisarev
7 Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-s-Signaling Pathway
85(14)
Gerard C. Blobe
PART II: GENERAL VACCINE AND IMMUNOTHERAPY STRATEGIES
8 Immune Adjuvants
99(16)
Jory R. Baldridge, Susan Hand Zimmermann, and Sally P. Mossman
9 Heterologous Prime-Boost Vaccination in Tumor Immunotherapy
115(6)
Michael J. Palmowski and Caroline Smith
10 Peptide-Based Vaccines
121(16)
Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, Kathy Schiffman, and Mary L. Disis
11 Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens
137(20)
Govind Ragupathi, John Gathuru, and Philip O. Livingston
12 Anti-Idiotype Vaccines
157(18)
Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, and Kenneth A. Foon
13 Pox Viral Vaccines
175(18)
James L. Gulley, Philip M. Arlen, and Jeffrey Schlom
14 Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches
193(10)
Zachary Hartman and Andrea Amalfitano
15 Alphaviral-Based Strategies for the Immunotherapy of Cancer
203(22)
Edward L. Nelson and Jonathan Smith
16 DNA Vaccines
225(24)
Michael Bereta and Howard L. Kaufman
17 Whole-Cell Vaccines
249(4)
Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, and Michael A. Morse
18 Gene-Modified Tumor-Cell Vaccines
253(22)
Leisha A. Enrens and Elizabeth M. Jaffee
19 Hapten-Modified Tumor Vaccines
275(22)
David Berd
20 Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines
297(20)
Michael W. Graner and Emmanuel Katsanis
21 Dendritic Cell Vaccines
317(14)
Madhav V. Dhodapkar
22 Exosomes for Immunotherapy of Cancer
331(10)
Nathalie Chaput, N.E.C. Schartz, Fabrice Andre, and Laurence Zitvogel
23 Immunocytokines for Cancer Immunotherapy
341(18)
Paul M. Sondel and Steven D. Gillies
24 T-Cell Adoptive Immunotherapy
359(20)
Gregory E. Plautz, Peter A. Cohen, David E. Weng, and Suyu Shu
PART III: TUMOR-SPECIFIC VACCINE DEVELOPMENT
25 Melanoma Vaccines
379(18)
Jeffrey Weber
26 Allogenic Melanoma Lysate Vaccines
397(18)
Malcolm S. Mitchell
27 Renal Cancer Vaccines
415(10)
Hyung L. Kim, Barbara J. Gitlitz, and Robert A. Figlin
28 Vaccines for Hematological Malignancies
425(26)
Qing Vi
29 Vaccines for the Immunotherapy of Prostate Cancer
451(14)
Boris Minev and Michael L. Salgaller
30 Vaccine Therapy for Breast and Ovarian Cancers
465(26)
Susan E. Smith and Alison T. Stopeck
31 Vaccine Therapy for Gastrointestinal Cancers
491(14)
John L. Marshall
32 Vaccines for Lung Cancer
505(8)
Michael A. Morse, Jennifer Garst, and Eric Toloza
33 Vaccines for Other Tumors
513(6)
Michael A. Morse
PART IV: CLINICAL TRIALS AND IMMUNE ANALYSES
34 Clinical Trial Designs for Therapeutic Vaccine Studies
519(8)
Richard Simon
35 Analysis of Cellular Immune Responses In Cancer Vaccine Trials
527(16)
Timothy M. Clay, Michael A. Morse, Paul J. Mosca, Amy Hobeika, Donna Niedzwiecki, and H. Kim Lyerly
36 Analysis of Humoral Immune Responses in Vaccine Trials
543(20)
Rajasekharan Somasundaram, Tiangian Zhang, and Dorothee Herlyn
37 Regulatory Issues Affecting Tumor Vaccines
563(14)
Mark O. Thornton, Alexandra S. Worobec, Keith Wonnacott, and Raj K. Purl
Index 577

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