Human Blood Plasma Proteins Structure and Function
by Schaller, Johann; Gerber, Simon; Kaempfer, Urs; Lejon, Sofia; Trachsel, ChristianEdition: 1st
Format: Hardcover
Pub. Date: 2008-06-03
Publisher(s): WILEY
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Summary
Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: introduction to blood components and blood plasma proteins blood plasma protein domains, motifs and repeats blood plasma protein families and posttranslational modifications blood coagulation and fibrinolysis the complement system the immune system enzymes inhibitors lipoproteins hormones cytokines and growth factors transport and storageThe information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure.Attractively presented in full colour, Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.
Author Biography
Johann Schaller and Simon Gerber are the authors of Human Blood Plasma Proteins: Structure and Function, published by Wiley.
Table of Contents
| Preface | p. xi |
| Introduction | p. 1 |
| References | p. 3 |
| p. 5 | |
| Blood Components | p. 7 |
| Introduction | p. 7 |
| Short History | p. 7 |
| Blood Components | p. 8 |
| Blood cells | p. 8 |
| Blood plasma | p. 12 |
| The blood group system | p. 13 |
| References | p. 15 |
| Data Sheet | p. 16 |
| Blood Plasma Proteins | p. 17 |
| Introduction | p. 17 |
| Short History | p. 17 |
| Classification of Blood Plasma Proteins | p. 17 |
| References | p. 20 |
| p. 21 | |
| Domains, Motifs and Repeats | p. 23 |
| Introduction | p. 23 |
| The Epidermal Growth Factor (EGF)-Like Domain | p. 24 |
| The Kringle Domain | p. 26 |
| The [gamma]-Carboxyglutamic Acid-Rich (Gla) Domain | p. 27 |
| The PAN/Apple Domain | p. 28 |
| The Sushi/CCP/SCR Domain | p. 30 |
| The Fibronectin Type I, the Fibronectin Type II Collagen-Binding and the Fibronectin Type III Domains | p. 31 |
| The Coagulation Factors 5/8 Type C Domain (FA58C) | p. 32 |
| The Thrombospondin Type I Repeat (TSP1) | p. 34 |
| The VWFA, VWFC and VWFD Domains | p. 35 |
| The Cystatin-Like Domain | p. 36 |
| The LDL-Receptor Class A (LDLRA) and Class B (LDLRB) Domains | p. 36 |
| The C-Terminal Cystine Knot (CTCK) Structure | p. 38 |
| The Anaphylatoxin Domain | p. 40 |
| The CUB Domain | p. 40 |
| The NTR Domain | p. 41 |
| The C-Type Lectin (CTL) Domain | p. 42 |
| The Ig-Like Domain | p. 43 |
| References | p. 44 |
| Protein Families | p. 47 |
| Introduction | p. 47 |
| Serine Proteases: The Trypsin Family | p. 47 |
| Serine Protease Inhibitors (Serpins) | p. 48 |
| The [alpha subscript 2]-Macroglobulin Family | p. 50 |
| The Serum Albumin Family | p. 52 |
| The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature | p. 52 |
| The Kazal Serine Protease Inhibitors Family Signature | p. 53 |
| The Multicopper Oxidase Family | p. 54 |
| The Lipocalin Family | p. 54 |
| The Globin Family | p. 55 |
| The Glucagon/Gastric Inhibitory Polypeptide (GIP)/Secretin/Vasoactive Intestinal Peptide (VIP) Family | p. 56 |
| The Glycoprotein Hormone Family | p. 58 |
| Membrane Attack Complex Components/Perforin Signature (The Complement C6/C7/C8/C9 Family) | p. 59 |
| The Lipase Family | p. 60 |
| Hormone Families and Signatures | p. 61 |
| The erythropoietin/thrombopoietin signature | p. 61 |
| The corticotropin-releasing factor family | p. 61 |
| The gonadotropin-releasing hormone signature | p. 62 |
| The calcitonin/CGRP/IAPP family | p. 62 |
| The gastrin/cholecystokinin family | p. 62 |
| The insulin family | p. 62 |
| Growth Factor Families | p. 64 |
| The platelet-derived growth factor family | p. 64 |
| The transforming growth factor-[beta] family | p. 64 |
| Cytokine Families | p. 65 |
| The tumor necrosis factor family | p. 65 |
| The interferon [alpha], [beta] and [delta] family | p. 66 |
| Interleukin Families and Signatures | p. 66 |
| The interleukin-1 signature | p. 66 |
| The interleukin-2 signature | p. 67 |
| The interleukin-4/-13 signature | p. 68 |
| The interleukin-6/granulocyte colony-stimulating factor/myelomonocytic growth factor family | p. 68 |
| The interleukin-7 and -9 signature | p. 69 |
| Interleukin-10 family | p. 69 |
| The Small Cytokine (Intercrine/Chemokine) Family and Signature | p. 70 |
| References | p. 72 |
| Posttranslational Modifications | p. 75 |
| Introduction | p. 75 |
| Databases for Posttranslational Modifications (PTMs) | p. 75 |
| Disulfide Bridges | p. 75 |
| Glycosylation | p. 77 |
| Phosphorylation | p. 79 |
| Ser/Thr phosphorylation sites | p. 80 |
| Tyr phosphorylation site | p. 81 |
| Hydroxylation | p. 81 |
| Aspartic acid and asparagine hydroxylation site | p. 81 |
| Sulfation | p. 82 |
| Acylation and Alkylation | p. 84 |
| Amidation | p. 84 |
| Carboxylation | p. 84 |
| Crosslinks | p. 85 |
| The isoglutamyl cysteine thioester bond | p. 85 |
| The isopeptide bond | p. 85 |
| References | p. 86 |
| p. 89 | |
| Blood Coagulation and Fibrinolysis | p. 91 |
| Introduction | p. 91 |
| Definition of haemostasis | p. 91 |
| Primary Haemostasis | p. 92 |
| The Coagulation Cascade | p. 95 |
| The Fibrinolytic System | p. 109 |
| The Regulation of Blood Coagulation and Fibrinolysis | p. 114 |
| The Kinin and Angiotensin/Renin Systems | p. 116 |
| References | p. 119 |
| Data Sheets | p. 121 |
| The Complement System | p. 151 |
| Introduction | p. 151 |
| Nomenclature | p. 152 |
| The Classical Pathway | p. 152 |
| The anaphylatoxins C3a, C4a and C5a | p. 160 |
| The Alternative Pathway | p. 160 |
| The Terminal Components of the Complement System | p. 162 |
| Components of Complement Activation | p. 165 |
| Regulation of the Complement System | p. 167 |
| References | p. 171 |
| Data Sheets | p. 172 |
| The Immune System | p. 195 |
| Introduction | p. 195 |
| Immunoglobulins | p. 196 |
| Antibody Diversity | p. 203 |
| Major Histocompatibility Complex (MHC) Proteins | p. 205 |
| Innate Immune System | p. 209 |
| Other Proteins | p. 213 |
| References | p. 214 |
| Data Sheets | p. 215 |
| Enzymes | p. 231 |
| Introduction | p. 231 |
| EC 1: Oxidoreductases | p. 231 |
| EC 1.11: peroxidases | p. 233 |
| EC 2: Transferases | p. 236 |
| EC 2.3: acyltransferases | p. 236 |
| EC 2.6: transfer of nitrogenous group | p. 237 |
| EC 2.7: transfer of phosphorous-containing groups | p. 237 |
| EC 3: Hydrolases | p. 239 |
| EC 3.1: esterases (ester bond) | p. 239 |
| EC 3.2: glycosylases (sugars) | p. 242 |
| EC 3.4: peptidases (peptide bonds) | p. 243 |
| EC 3.4.17: metallocarboxypeptidases | p. 243 |
| EC 3.4.21: serine endopeptidases (serine proteases) | p. 243 |
| EC 3.4.22: cysteine endopeptidases (cysteine proteases) | p. 250 |
| EC 3.4.23: aspartic endopeptidases (aspartic proteases) | p. 253 |
| EC 5: Isomerases | p. 255 |
| EC 5.3: oxidoreductases (intramolecular) | p. 256 |
| References | p. 257 |
| Data Sheets | p. 258 |
| Inhibitors | p. 283 |
| Introduction | p. 283 |
| Serine Protease Inhibitors (Serpins) | p. 283 |
| Introduction | p. 283 |
| Structural properties | p. 284 |
| Inhibitory reaction | p. 286 |
| Blood Coagulation and Fibrinolysis | p. 286 |
| Blood coagulation | p. 287 |
| Fibrinolysis | p. 291 |
| The Complement System | p. 292 |
| General Inhibitors | p. 293 |
| Other Serpins | p. 294 |
| Other Inhibitors | p. 294 |
| References | p. 298 |
| Data Sheets | p. 299 |
| Lipoproteins | p. 317 |
| Introduction | p. 317 |
| Enzymes in Lipoprotein Metabolism | p. 318 |
| Apolipoproteins | p. 320 |
| LDL and VLDL Receptors | p. 324 |
| Serum Amyloid A Proteins | p. 325 |
| References | p. 326 |
| Data Sheets | p. 327 |
| Hormones | p. 343 |
| Introduction | p. 343 |
| Pancreatic Hormones | p. 343 |
| Gastrointestinal Hormones | p. 346 |
| Calcium-Related Hormones | p. 347 |
| Hormone-Releasing Factors, Their Trophic Hormones and Related Hormones | p. 349 |
| Vasopressin and Oxytocin | p. 355 |
| Natural Opioid Peptides | p. 356 |
| Vasoactive Peptides | p. 357 |
| Erythropoietin and Thrombopoietin | p. 359 |
| Others | p. 360 |
| Adiponectin | p. 360 |
| Islet amyloid polypeptide | p. 360 |
| References | p. 361 |
| Data Sheets | p. 362 |
| Cytokines and Growth Factors | p. 393 |
| Introduction | p. 393 |
| Interleukin Families | p. 395 |
| Interleukin-1 family | p. 395 |
| Interleukin-2 family | p. 397 |
| Interleukin-3 family | p. 397 |
| Interleukin-4/interleukin-13 family | p. 398 |
| Interleukin-5 family | p. 398 |
| Interleukin-6 family | p. 400 |
| Interleukin-7/interleukin-9 family | p. 402 |
| Interleukin-10 family | p. 402 |
| Interleukin-15 family | p. 404 |
| Granulocyte-macrophage colony-stimulating factor family | p. 404 |
| Tumour Necrosis Factor Family | p. 405 |
| The Interferon Family | p. 406 |
| The interferon [alpha]/[beta] family | p. 406 |
| The interferon [gamma] family | p. 408 |
| Chemokines | p. 408 |
| The intercrine [alpha]/chemokine CxC family | p. 409 |
| The intercrine [beta]/chemokine CC family | p. 410 |
| The Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Family | p. 413 |
| Transforming Growth Factor-[beta] Family | p. 414 |
| Miscellaneous | p. 415 |
| The nerve growth factor-[beta] family | p. 415 |
| Epidermal growth factor | p. 417 |
| Insulin-like growth factor binding proteins | p. 418 |
| References | p. 418 |
| Data Sheets | p. 419 |
| Transport and Storage | p. 451 |
| Introduction | p. 451 |
| The Serum Albumin Family | p. 451 |
| The Globin Family | p. 452 |
| Haptoglobin | p. 456 |
| Iron Transport and Storage | p. 457 |
| Iron oxidation: ceruloplasmin | p. 457 |
| Iron transport proteins: transferrins | p. 459 |
| Iron storage | p. 462 |
| Heme transport and iron recovery: hemopexin | p. 462 |
| Transport of Hormones, Steroids and Vitamins | p. 463 |
| Hormone transport proteins | p. 464 |
| Steroid transport proteins | p. 467 |
| Vitamin A transport protein | p. 467 |
| Other Transport Proteins in Plasma | p. 468 |
| Selenoproteins | p. 468 |
| References | p. 468 |
| Data Sheets | p. 469 |
| Additional Proteins | p. 487 |
| Introduction | p. 487 |
| Additional Blood Plasma Proteins | p. 487 |
| Data Sheets | p. 492 |
| Appendix | p. 503 |
| Glossary | p. 515 |
| Index | p. 521 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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