Human Germ-Line Gene Therapy: Scientific, Moral, and Political Issues,9781570595868

Human Germ-Line Gene Therapy: Scientific, Moral, and Political Issues

by ; ;
ISBN13: 9781570595868
ISBN10: 1570595860
Format: Hardcover
Pub. Date: 1999-02-01
Publisher(s): R G Landes Co
List Price: $119.00

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Summary

Medical Intelligence Unit 9> East Carolina Univ., Greenville. Provides an assessment of the possible benefits and risks implicated by genetic engineering. Includes a description of the current state of medical genetics and technologies. Addresses moral, social, and political recommendations. For researchers and clinicians. DNLM: Gene Therapy.

Table of Contents

From Genes to Disease
1(16)
Scope of the Term Gene Therapy
1(1)
Some Common Misconceptions
2(2)
Gene Expression
4(4)
Genes, Mutations and Inheritance
8(6)
Summary and Conclusion
14(3)
Alternatives to Human Germline Gene Therapy
17(30)
Introduction
17(1)
Genetic Disease and Testing
18(2)
When in Vitro Fertilization is Not an Acceptable Option
20(4)
When In Vitro Fertilization and Embryo Selection Are Acceptable Options
24(11)
Some Methods of Analysis in Single-cell Genetics
35(4)
Prenatal Diagnosis
39(2)
When Germline Genetic Manipulation Is an Option
41(1)
Summary and Conclusions
42(5)
Gene Delivery Systems
47(24)
Introduction
47(1)
Targets of Gene Therapy
47(3)
Transgene Destination and Expression
50(5)
Consequences of Transgene Destination and Expression in SGT or HGLGT
55(1)
Methods of Gene Transfer
56(10)
Summary and Conclusions
66(5)
Challenges of Human Germline Gene Therapy
71(14)
HGLGT Targets
71(1)
Transgenic Animals
72(1)
Examples of Approaches in HGLGT
73(6)
Technical Obstacles in HGLGT
79(3)
SGT Obstacles That Are Not HGLGT Obstacles
82(1)
Summary and Conclusions
83(2)
Therapy vs. Enhancement and Other Pertinent Distinctions
85(8)
Some Ethical Questions in Embryo Selection and HGLGT
86(1)
Gene Therapy vs. Genetic Enhancement
86(3)
Parental Choice vs. State Controls
89(1)
Genetic Determinism
89(1)
Moral and Political Decision Making
90(3)
Potential Benefits and Harms of Human Germline Gene Therapy
93(20)
The Logic of Benefit/Harm Arguments
93(2)
Medical Benefits/Harms
95(6)
Evolutionary Benefits/Harms
101(4)
Psychosocial Benefits/Harms
105(2)
Economic Benefits/Costs
107(2)
Conclusion: Optimism, Pessimism, or Prudence?
109(4)
Human Germline Gene Therapy, Rights and Responsibilities
113(16)
What Are Rights and Responsibilities?
113(3)
Parental Rights
116(1)
HGLGT and Harms to Unborn Children
117(4)
Is Nonexistence a Harm?
121(1)
Harms to Future Generations
122(2)
Other Rights Considerations
124(2)
Conclusion
126(3)
Human Germline Gene Therapy and Justice
129(16)
What Is Justice?
129(2)
HGLGT and Human Equality
131(2)
Equality of Opportunity
133(4)
Two Objections to Defining a Normal Range of Variation
137(3)
Genetic Discrimination
140(2)
Conclusion
142(3)
Human Germline Gene Therapy and Our Humanness
145(12)
Human Germline Gene Therapy and Our Humanness
145(3)
HGLGT's Effects on Our Humanness
148(1)
Changing our Humanness
149(1)
HGLGT and Natural Law
150(2)
HGLGT and ``Playing God''
152(2)
The ``Who Decides?'' Question
154(1)
HGLGT and Human Perfection
154(1)
Conclusion
155(2)
Public Policy Issues
157(12)
Science and Public Policy
157(2)
Research Restrictions
159(1)
HGLGT Funding
160(2)
Privacy
162(1)
Discrimination and Bias
162(1)
HGLGT Patents
162(2)
International Cooperation
164(1)
Monitoring Research
165(1)
Welfare and Enhancement
165(1)
Conclusion
166(3)
Glossary 169(14)
Index 183

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