Immunology, Immunopathology, and Immunity,9781555812027

Immunology, Immunopathology, and Immunity

by ;
Edition: 6th
ISBN13: 9781555812027
ISBN10: 1555812023
Format: Hardcover
Pub. Date: 2001-04-01
Publisher(s): Amer Society for Microbiology
List Price: $59.95

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Summary

The Albany Medical College, Albany, NY. Text outlining what the immune system is, what it does, and how it works, for medical students. Features numerous figures and illustrations, with a bibliography at the end of each chapter. Answers clinically-related questions about the role of immune response in disease prevention. Previous edition: c1996. DNLM: Immune system--physiology.

Table of Contents

Preface xix
I Immunology 1(232)
Introduction to Part I
3(7)
Immunity
3(3)
Innate Immunity
4(1)
Adaptive Immunity
4(2)
The Inflammatory Response
6(2)
Immunopathology (the Double-Edged Sword)
8(1)
Summary
8(1)
Bibliography
9(1)
Cells of the Immune System
10(23)
The Blood and Lymphoid Systems
10(1)
Blood Cells
10(14)
Red Blood Cells
10(1)
White Blood Cells
11(13)
Cellular Interactions in Immune Responses
24(1)
Hematopoiesis (Blood Formation)
25(5)
Hematopoietic Factors
27(1)
Hematopoietic Factor Treatment of Human Diseases
27(3)
Summary
30(1)
Bibliography
30(3)
Inflammation and Wound Healing
33(68)
The Inflammatory Process
33(2)
Acute Inflammation
35(3)
Initiation of Inflammation
35(1)
Chemical Mediators
35(1)
Gross Manifestations
36(1)
Histologic Features
36(2)
Classification of Inflammation
38(1)
The Cells of Acute Inflammation
38(16)
Mast Cells
38(1)
Fce Receptors
38(1)
Mast Cell Mediators
39(1)
Histamine
40(4)
Platelets
44(1)
Polymorphonuclear Neutrophils
45(2)
Adhesion Molecules
47(6)
Eosinophils
53(1)
Serum Protein Systems
54(15)
Complement
54(9)
The Coagulation System
63(3)
The Kinin System
66(1)
Acute-Phase Reactants
66(3)
Adult Respiratory Distress Syndrome
69(1)
Interrelationships of Inflammatory Cells and Protein Systems in Acute Inflammation
69(2)
Chronic Inflammation
71(1)
The Cells of Chronic Inflammation
71(6)
Lymphocytes
71(1)
Macrophages
72(5)
Cytokines in Chronic Inflammation
77(3)
IL-1
77(1)
IL-2
78(1)
IFN-γ
78(1)
MIF
79(1)
TGF-β1
79(1)
TNF
80(1)
Chemokines
80(3)
Apoptosis
83(2)
Death Receptors
83(1)
Caspases
84(1)
The Bcl Family
84(1)
Wound Healing
85(3)
Growth Factors
85(2)
Adhension Molecules
87(1)
Review of Mediators of Inflammation
88(1)
Manifestations of Inflammation in Tissues
89(1)
Cytokines, Adhesion Molecules, and Growth Factors in Atherosclerosis
90(1)
Amyloidosis
91(4)
Classification
92(1)
Amyloidogenic Proteins
92(3)
Alzheimer's Disease
95(1)
Summary
96(1)
Bibliography
96(5)
All about B Cells
101(49)
B Cells and Antibodies
101(1)
Antibodies
101(4)
Antigen Binding
103(1)
Clonal Selection
104(1)
Immunoglobulin Structure
105(12)
Isotypes
105(1)
Prototype Molecule
105(2)
Variable and Constant Domains
107(1)
Effector Functions
108(1)
Fc Receptors
109(2)
Human Heavy-Chain Isotypes
111(3)
Light-Chain Isotypes
114(1)
Diversity of Antibody Specificity
114(2)
Antigenic Determinants (Epitopes)
116(1)
Idiotypes
116(1)
Xenotypes and Allotypes
117(1)
Antibody-Antigen Reactions
117(12)
Precipitin Reaction
117(1)
Immunodiffusion
118(2)
Immunoelectrophoresis
120(1)
Agglutination
121(1)
Complement Fixation
121(1)
Radioimmunoassay
122(1)
Immunolabeling
122(4)
Antibody Affinity Chromatography
126(1)
Neutralization Tests
127(1)
Antigen-Antibody Reaction In Vivo
128(1)
The B-Cell Receptor (BCR)
129(2)
The BCR as a Signal Transducer
129(1)
The BCR in Antigen Presentation
130(1)
Immunoglobulin Genes
131(11)
Generation of Diversity
131(1)
Light-Chain V Gene Assembly
131(4)
Heavy-Chain Diversity
135(7)
B-Cell Development
142(2)
Ig Gene Expression
142(1)
CD Markers of B-Cell Differentiation
142(1)
B-Cell Tolerance
142(2)
Gene Rearrangements in Lymphomas and Leukemias
144(1)
Application of Antibody Technology to Therapy
145(2)
Summary
147(1)
Bibliography
147(3)
All about T Cells and Induction of Immunity
150(48)
T Cells and the Immune Response
150(6)
T-Cell Recognition of Antigens
150(1)
Clonal Expansion of T Cells
151(2)
T-Cell Cloning
153(1)
T-Cell Hybridomas
153(1)
T-Cell Epitope Mapping
153(3)
The T-Cell Receptor
156(3)
Structure
156(2)
Chromosomal Location
158(1)
Superantigens
158(1)
T-Cell Activation
159(11)
Antigen Signaling
159(1)
Tyrosine Kinases
159(3)
Tec Kinases
162(1)
CD45
162(1)
Phospholipase Cyl
163(1)
The Ras Pathway
163(1)
IL-2 and IL-2 Receptors
164(1)
The Jak/STAT Pathway
164(1)
Antigen Processing and Presentation
164(1)
Endosomal or Exogenous Processing
165(1)
Nonendosomal or Endogenous Processing
165(3)
Peptide-MHC Binding
168(2)
The Major Histocompatibility Complex
170(4)
Structure
171(1)
Inheritance
171(1)
HLA Matching
171(2)
Self Recognition
173(1)
T-Cell-B-Cell Interactions, the MHC, and the Immune Response
174(6)
MHC Recognition by T Cells
175(1)
Activation Signals
176(2)
T-Cell Populations and Control of the Immune Response
178(2)
Prophylactic Immunization (Vaccination)
180(11)
History: Smallpox
180(2)
Vaccination for Antibody Production
182(1)
Vaccine Design: Influenza Virus
183(2)
Vaccine Potency: Haemophilus influenzae
185(1)
Control of the Type of Immune Response
186(5)
Summary
191(2)
Bibliography
193(5)
Lymphoid Organs
198(35)
The Lymphatic System: Vessels and Organs
198(3)
Lymphatic Vessels
198(3)
Lymphoid Organs: Structure and Function
201(24)
Central Lymphoid Organs
201(6)
Peripheral Lymphoid Organs
207(9)
Innervation of Lymphoid Organs
216(1)
Comparison of the Structures of Lymphoid Organs
217(1)
Lymphocyte Circulation
217(2)
The Effect of Antigens on Lymphoid Tissue
219(5)
Normal Lymphoid Traffic
224(1)
Activated Lymphoid Traffic
224(1)
Development of Lymphoid Organs (Ontogeny)
225(2)
Hematopoiesis
225(2)
Summary
227(1)
Bibliography
227(6)
II Immunopathology and Immunity 233(452)
Introduction to Part II
235(5)
Immunity, Immunopathology, Hypersensitivity, and Allergy
235(1)
Immune Effector Mechanisms
236(2)
Antibody-Directed Immune Effector Mechanisms
236(1)
Cell-Mediated Immune Effector Mechanisms
237(1)
The ``Double-Edged Sword'' of Immune Defense Mechanisms
238(1)
Bibliography
239(1)
Inactivation and Activation of Biologically Active Molecules
240(36)
Mechanisms of Antibody-Mediated Inactivation and Activation
240(4)
Inactivation
240(3)
Activation
243(1)
Examples of Antibody-Mediated Inactivation and Activation
244(16)
Hormones
244(5)
Receptors
249(9)
Other Biologically Active Molecules
258(1)
Other Antibodies
259(1)
Ligands, Receptors, and Idiotypes
260(1)
Anti-Idiotypes and Ligand Mimicry
260(1)
Anti-Idiotypes and Disease
260(1)
Neutralizing Antibodies: Cause and Effect
261(1)
Protective Functions of Inactivating (Neutralizing) Antibodies
262(8)
Tetanus
263(2)
Diphtheria
265(1)
Viral Neutralization
266(4)
Summary
270(1)
Bibliography
270(6)
Cytotoxic and Cytolytic Reactions
276(26)
The Mechanism of Cytolytic Reactions
276(2)
Immunohematologic Diseases
278(13)
Erythrocytes (Anemia)
278(10)
Leukocytes (Agranulocytosis)
288(1)
Platelets
289(1)
Immune Suppression of Blood Cell Production
290(1)
Cytolytic Skin Diseases
291(1)
Other Cytotoxic Reactions
291(1)
Sperm
291(1)
Autoimmune Diseases
292(1)
Homograft Rejection
292(1)
Detection of Circulating Cytotoxic Antibodies
292(1)
Passive Transfer (In Vivo)
292(1)
Coombs' Test (In Vitro)
292(1)
Protective and Pathologic Effects in Infectious Diseases
293(6)
Malaria
293(6)
Summary
299(1)
Bibliography
299(3)
Immune Complex Reactions
302(57)
Immune Complexes in Vivo
302(1)
The Arthus Reaction
302(2)
Serum Sickness
304(3)
Immune Complexes in Infectious Diseases
307(1)
Glomerulonephritis
308(10)
Acute Glomerulonephritis
308(4)
Chronic Glomerulonephritis
312(1)
Anti-Glomerular Basement Nephritis
313(1)
Other Glomerulopathies
314(2)
Renal Tubular Disease
316(1)
Clinical-Immunopathologic Correlations in Glomerulonephritis
317(1)
Human Glomerular Diseases
318(1)
Vasculitis
318(5)
Behcet's Syndrome
320(1)
Kawasaki Syndrome (Mucocutaneous Lymph Node Syndrome)
320(2)
Hypocomplementemic Vasculitic Urticarial Syndrome
322(1)
Giant Cell Arteritis
322(1)
Post-Cardiac Bypass Syndrome
322(1)
Aleutian Mink Disease
322(1)
Dermal Vasculitis
322(1)
Cutaneous Vasculitis in Infectious Diseases
322(1)
Rheumatic Fever
323(2)
Diffuse Connective Tissue Diseases
325(27)
Polyarteritis Nodosa
327(1)
Rheumatoid Arthritis
328(6)
Spondyloarthropathies and HLA-B27
334(1)
Systemic Lupus Erythematosus (SLE)
335(9)
Sjogren's Syndrome (Sicca Complex)
344(2)
Inflammatory Myopathies (Dermatomyositis and Polymyositis)
346(2)
Progressive Systemic Sclerosis (PSS, or Scleroderma)
348(2)
Mixed Connective Tissue Disease and Overlap Syndromes
350(1)
Thrombotic Microangiopathies
351(1)
Summary
351(1)
Other Immune Complex Diseases
352(1)
Cellular Interstitial Pneumonia
352(1)
Arthritis
352(1)
Choroid Plexus Deposition
352(1)
Uveitis
352(1)
Evaluation of Circulating Immune Complexes
353(1)
Summary
353(1)
Bibliography
353(6)
Atopic and Anaphylactic Reactions (Allergy)
359(42)
Introduction
359(3)
Definitions
359(1)
Histamine Receptors
360(1)
Comparison of Anaphylactic and Atopic Reactions
361(1)
Allergens
362(1)
Allergic Sensitization
362(1)
Chemistry of Allergens
362(1)
Natural Distribution of Allergens
363(1)
Reaginic Antibody
363(4)
IgE Antibody
364(1)
Passive Anaphylaxis
364(1)
Clinical Antibody Tests (In Vivo)
365(1)
Laboratory Tests (In Vitro)
366(1)
Mediator Release from Mast Cells
367(1)
Anaphylaxis
367(2)
Cutaneous Anaphylaxis
367(1)
Systemic Anaphylaxis
367(2)
Idiopathic Anaphylaxis
369(1)
Atopic Allergy
369(1)
Route of Access of Antigen
369(1)
Dose of Antigen
369(1)
``The Shock Organ''
369(1)
Familial Susceptibility (Genetics)
370(1)
Asthma
370(5)
Predisposing Factors
371(1)
Intrinsic Asthma
372(1)
Nonimmune Asthma
372(1)
Pathologic Changes
372(2)
Therapy
374(1)
Atopic Reactions
375(5)
Hay Fever (Seasonal Allergic Rhinitis)
375(1)
Nasal Polyps
376(1)
Food Allergy
377(1)
Insect Allergy
377(2)
Atopic Eczema-Atopic Dermatitis
379(1)
Aspirin Intolerance
379(1)
Urticaria and Angioedema
380(3)
Anaphylactoid Reactions
381(1)
Hereditary Angioedema
382(1)
Immunotherapeutic Modification of Atopic Allergy
383(4)
Hyposensitization
384(1)
Desensitization
385(1)
Tolerance
385(1)
Suppression
385(1)
Increased Serum IgE
386(1)
Anti-IgE
386(1)
Pharmacologic Control of Atopic Reactions
387(4)
Mast Cells
388(1)
End-Organ Sensitivity
388(1)
The Autonomic Nervous System
389(1)
Autoantibodies of β-Adrenergic Receptors
389(2)
Treatment of Allergies
391(3)
Protective Role of IgE
391(1)
Bacterial Infections
392(1)
Intestinal Parasites
392(1)
Avoidance of Allergy
393(1)
Allergic Bronchopulmonary Aspergillosis
393(1)
Summary
394(1)
Bibliography
395(6)
T-Cell-Mediated Cytotoxicity
401(30)
Cell-Mediated Immunity
401(1)
TCTL, TDTH, and Natural Killer Cells
401(3)
T-Cell Killing
402(1)
NK Cell Killing
402(2)
Induction of T-Cell Immunity
404(1)
TCTL-Cell Reactions in Vitro
405(1)
TCTL-Cell Reactions In Vivo
406(21)
Contact Dermatitis
406(3)
Tissue Graft Rejection
409(8)
Pregnancy: a Tolerated Graft
417(2)
Transplantation Summary
419(1)
Viral Exanthems
420(1)
Viral Hepatitis
420(3)
Warts
423(1)
Autoimmune Disease
423(4)
Summary
427(1)
Bibliography
427(4)
Delayed-Type Hypersensivitiy
431(21)
TDTH-Cell Reactions: Delayed-Type Hypersensitivity
431(1)
TDTH-Cell Activation and Superantigens
432(2)
Delayed-Type Hypersensitivity Skin Reaction
434(2)
Cutaneous Basophil Hypersensitivity
436(1)
Transfer Factor
436(1)
Delayed-Type Hypersensitivity and Infection
437(2)
Syphilis
437(2)
TDTH-Cell-Mediated Autoimmune Disease
439(4)
Experimental Allergic Encephalomyelitis
439(2)
Human Encephalomyelitis and Multiple Sclerosis
441(1)
Experimental Allergic Neuritis
442(1)
Experimental Allergic Sympathetic Neuritis
442(1)
Viral Encephalitis
443(4)
Animal Models of Viral Encephalitis
443(2)
Viral Encephalitides of Humans
445(2)
TCTL and TDTH Cells, Tuberculosis, and Leprosy
447(1)
Summary
448(1)
Bibliography
448(4)
Granulomatous Reactions
452(26)
The Nature of Granulomas
452(3)
Granulomatous Diseases
455(18)
Infectious Diseases
455(11)
Granulomatous Responses to Known Antigens
466(2)
Diseases of Unknown Etiology
468(4)
Immune Deficiency Diseases
472(1)
Protective Functions of Granulomatous Reactions
472(1)
Summary
473(1)
Bibliography
473(5)
Interplay of Inflammatory and Immunopathologic Mechanisms, Immune Defense, and Evasion of Immune Defense Mechanisms during Infection
478(32)
Nonimmune Inflammation
478(1)
Immune Inflammation
478(3)
Interaction of Immune and Nonimmune Inflammation
481(1)
Immune-Specific Protection against Infection
481(7)
Bacterial Infections
482(2)
Viral Infections
484(1)
Mycobacterial Infections
484(1)
Protozoal Infections
485(1)
Helminth (Worm) Infections
486(1)
Fungal Infections
487(1)
Insect Stings
487(1)
Summary of the Role of Immune Mechanisms in Protection against Infections
487(1)
Interaction of Immune Mechanisms in Some Infectious Diseases
488(4)
Lyme Disease
488(2)
Strongyloides Hyperinfection
490(2)
Evasion of Immune Defense Mechanisms
492(13)
Echinococcosis: Protected Niche
494(1)
HIV: Intracellular Location and Immunosuppression
494(1)
Chlamydia trachomatis: Endosomes
494(1)
Streptococus pneumoniae: Resistance to Phagocytosis
494(1)
Mycobacterium tuberculosis: FasL Expression
495(1)
Schistosomiasis: Protective Niche, Masking of Surface Antigens, Complement Misdirection, and Th1-versus-Th2 Response
495(1)
Vaccinia Virus: Control of Complement Activation
496(1)
Trypanosomiasis: Antigenic Modulation
496(1)
Measles: Immunosuppression
497(1)
Influenza Virus: Stearic Hindrance
498(1)
Herpes Simplex Virus: Intracellular Location, Bipolar Bridging, and Complement Inhibition
498(1)
Malaria: FasL Expression, Antibody-Mediated Infection, and Peptide Inhibition of Antigen Presentation
499(1)
Ascaris lumbricoides: Extracorporeal Location and MHC-Restricted Recognition
499(1)
Adenovirus: Downregulation of Class I MHC and Inhibition of Apoptosis
500(1)
Cytomegalovirus: Class I and II MHC Degradation and Molecular Decoys
500(1)
Leprosy and Syphilis: Immune Deviation
501(1)
Poxviruses: Effector Modulation and Soluble Receptors
502(1)
Epstein-Barr Virus: IL-10
502(1)
Leishmaniasis: Complement-Mediated Endocytosis, Inhibition of Macrophage Killing, Modulation of T-Cell Immunity, and Immune Deviation
503(2)
Summary
505(2)
Bibliography
507(3)
Immune-Mediated Skin Diseases
510(18)
The Skin Immune System
510(3)
The Perivascular Unit
510(1)
Functions of the Skin Immune System
511(2)
Antibody-Mediated Skin Diseases
513(1)
Inactivation or Activation
513(2)
Pemphigus and Pemphigoid
513(2)
Epidermolysis Bullosa Acquisita
515(1)
Cytotoxic or Cytolytic Reactions
515(2)
Dermatitis Herpetiformis and Gluten-Sensitive Enteropathy (Sprue, or Celiac Disease)
516(1)
Herpes Gestationis
516(1)
Lupus Erythematosus
516(1)
Dermatomyositis
517(1)
Vitiligo
517(1)
Alopecia
517(1)
Immune Complex Reactions
517(1)
Erythema Nodosum
518(1)
Erythema Marginatum
518(1)
Cutaneous Vasculitis in Infectious Diseases
518(1)
Anaphylactic Reactions
518(2)
Mastocytosis
518(1)
Cutaneous Anaphylaxis
519(1)
Giant Urticaria
519(1)
Angioedema
519(1)
Hypocomplementemic Vasculitic Urticarial Syndrome
520(1)
Atopic Dermatitis
520(1)
Cell-Mediated Reactions
520(3)
T-Cytotoxic Reactions
520(2)
Delayed-Type Hypersensitivity Reactions
522(1)
Granulomatous Lesions
523(1)
Gumma
523(1)
Zirconium Granulomas
523(1)
Leprosy
523(1)
Sarcoidosis
524(1)
Disorders of Coagulation
524(1)
Summary
524(1)
Bibliography
524(4)
Immunoproliferative Diseases
528(28)
Leukemias and Lymphomas
528(1)
Maturation of Blood-Forming Cells and Leukemia
529(1)
Lymphoid Tissue Structure and Lymphoproliferative Disease
529(1)
Tissue Localization of Lymphoid Cells
529(1)
Nonmalignant Lymphoproliferation
529(3)
Malignant Lymphomas
532(19)
Non-Hodgkin's Lymphomas
533(12)
Hodgkin's Lymphoma
545(3)
Angioimmunoblastic Lymphadenopathy
548(1)
Etiology of Lymphomas
549(2)
Infections Associated with Lymphoproliferative Diseases
551(1)
Summary
551(1)
Bibliography
552(4)
Immunodeficiency Diseases
556(34)
Immune Deficiencies and Infections
556(2)
Immune Response of Immature Animals
557(1)
Hypogammaglobulinemia of Infancy
557(1)
Neonatal Wasting Syndrome (TORCH)
558(1)
Primary Immunodeficiencies
558(15)
Mouse Models of Primary Immunodeficiencies
559(1)
Severe Combined Immunodeficiencies
559(4)
T-Cell Activation Deficiencies
563(2)
Defects in DNA Repair
565(1)
Other T-Cell Deficiencies
565(1)
B-Cell Immunodeficiencies
566(2)
Inflammatory Defects
568(5)
Secondary Immunodeficiencies
573(4)
Iatrogenic Deficiencies
573(1)
Infectious Diseases
574(2)
Malcirculation of Lymphocytes
576(1)
Trauma
576(1)
Chronic Fatigue Syndrome
576(1)
Opportunistic Infections
577(1)
Evaluation of Immunodeficiency
578(1)
Therapy
579(7)
Passive Antibody
579(1)
Passive Cell-Mediated Antibody
580(6)
Summary
586(1)
Bibliography
587(3)
Immunology of AIDS
590(38)
Human Immunodeficiency Virus
590(8)
AIDS-Related Retroviruses
590(2)
The HIV Genome
592(1)
HIV Replication and Gene Expression
593(1)
The HIV Replicative Cycle
594(3)
Immune Evasion
597(1)
AIDS
598(23)
Epidemiology
598(1)
HIV Transmission
599(1)
Natural History of HIV Infection
600(4)
Cellular Dynamics of HIV Infection
604(1)
Immune Stimulation and Activation of AIDS
604(2)
Laboratory Diagnosis of HIV Infection
606(2)
Immune Dysfunction in AIDS
608(1)
Pathology and Clinical Staging
609(2)
Therapy
611(4)
Animal Models
615(1)
Vaccination against HIV Infection
616(5)
Summary
621(2)
Bibliography
623(5)
Tumor Immunity
628(57)
History of Tumor Immunity
628(1)
Evidence for Tumor Immunity in Humans
628(3)
Carcinogenesis and Tumor Immunity
631(1)
Types of Tumor Antigens
632(6)
TSTAs
632(2)
The Immune Response of the Primary Tumor-Bearing Host and Concomitant Immunity
634(1)
Etiology and Immunogenicity of Tumors
634(1)
Virus-Induced Tumor Antigens
635(2)
ODTAs
637(1)
Mechanisms of Tumor Cell Destruction by the Immune System
638(4)
In Vitro Assays of Tumor Immunity
638(3)
Antibody-Mediated Tumor Immunity
641(1)
In Vivo Tumor Killing
641(1)
Immunosurveillance
642(5)
The Phenomenon
642(1)
Failure of Immunosurveillance
643(4)
Immunodiagnosis of Cancer
647(15)
Myeloma Proteins
650(1)
AFP
651(1)
CEA
651(1)
PSA
652(1)
MAbs to Cancer Markers
653(2)
Cell Surface Carbohydrates
655(3)
Mucins
658(1)
Gangliosides
658(1)
Mixed Markers
658(2)
Cytoskeletal Elements
660(1)
Immunoglobulin Gene Rearrangements
660(1)
Oncogene Products
661(1)
Cancer Marker Summary
661(1)
Immunotherapy of Cancer
662(14)
Therapeutic Approaches
662(1)
History of Immunotherapy
662(3)
Evaluation of Immunotherapy
665(1)
BCG
665(1)
DNCB
666(1)
Interferon
666(1)
IL-2
667(1)
TILs
668(1)
CMV and T-Killer Adoptive Immunotherapy
669(1)
TNF
669(1)
IL-12
670(1)
CD40 Ligand
670(1)
MAbs: Magic Bullets
670(2)
Gene Therapy
672(1)
Human Tumor Antigens
672(1)
Antigen-Targeted Adoptive Transfer Therapy
673(1)
Tumor Vaccines
673(3)
Summary
676(1)
Bibliography
676(9)
Appendix 1 History of Immunopathology 685(6)
Appendix 2 Evolution of Immunity (Phylogeny) 691(6)
Appendix 3 Cluster-of-Differentiation Molecules 697(20)
Appendix 4 Cytokines 717(4)
Appendix 5 Clinical Immunology Tests 721(6)
Appendix 6 Tables of Lymphoproliferative Diseases 727(4)
Index 731

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