Inflammation and Allergy Drug Design
by Izuhara, K.; Holgate, Stephen T.; Wills-Karp, MarshaEdition: 1st
Format: Hardcover
Pub. Date: 2011-09-26
Publisher(s): Wiley-Blackwell
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Summary
This book educates the reader on the molecular and cellular mechanism of allergic diseases in the respiratory tract covering all aspects, from its immunological basis to its application in drug development. In contrast to other books, this book focuses on well-known and newly-emerging cells, cytokins, and mediators involved in the pathogenesis of allergic diseases in the respiratory tract. In particular, this book emphasises the findings of novel drug targets. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development.
Author Biography
Edited by
K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan
Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK
Marsha Wills-Karp, PhD, Children’s Hospital Medical Center, Cincinnati, USA
K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan
Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK
Marsha Wills-Karp, PhD, Children’s Hospital Medical Center, Cincinnati, USA
Table of Contents
| Contributors | p. vii |
| Preface | p. xiii |
| Cells contributing to the pathogenesis of allergic diseases in the respiratory tract | |
| Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells | p. 3 |
| Role of Th2 cells in the allergic diathesis | p. 15 |
| Importance of Th17- and Th1-associated responses for the development of asthma | p. 27 |
| Regulatory T cells | p. 39 |
| A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders | p. 59 |
| Regulatory roles of B cells in allergy and inflammation | p. 67 |
| Mast cells | p. 79 |
| Eosinophils | p. 107 |
| Basophils in inflammation and allergy drug design | p. 123 |
| Epithelial cells | p. 139 |
| Fibroblasts | p. 149 |
| Airway smooth muscle ceils | p. 163 |
| Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract | |
| Interleukin 4, interleukin 13, and interleukin 9 | p. 175 |
| Interleukin 3, interleukin 5, and granulocyte-macrophage colony-stimulating factor | p. 187 |
| Interleukin 15, interleukin 17, and interleukin 25 | p. 197 |
| Thymic stromal lymphopoietin | p. 205 |
| Interleukin 10 | p. 215 |
| Tumor necrosis factor alpha | p. 225 |
| Profibrotic and angiogenic factors in asthma | p. 237 |
| Chemokines | p. 253 |
| Epithelial growth factors | p. 263 |
| Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract | |
| Prostanoids | p. 273 |
| Leukotrienes | p. 285 |
| Proteases in allergy | p. 297 |
| Toll-like receptors | p. 307 |
| Index | p. 317 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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