Organic Synthesis Strategy and Control

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Edition: 1st
Format: Hardcover
Pub. Date: 2007-06-05
Publisher(s): WILEY
List Price: $232.47

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Summary

Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice.The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapterStudents and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Author Biography

Paul Wyatt, Senior Lecturer and Director of Undergraduate Studies, School of Chemistry, University of Bristol, UK and Stuart Warren, Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.

Table of Contents

Preface
Introduction: Selectivity
Planning Organic Syntheses: Tactics, Strategy, and Control
Chemoselectivity
Regioselectivity: Controlled Aldol Reactions
Stereoselectivity: Stereoselective Aldol Reactions
Alternative Strategies for Enone Synthesis
Choosing a Strategy : The Synthesis of cyclopentenones
Making Carbon-Carbon Bonds
The Ortho Strategy for Aromatic Compounds
I'-Complexes of Metals
Controlling the Michael Reaction
Specific Enol Equivalents
Extended Enolates
Allyl Anions
Homoenolates
Acyl Anion Equivalents
Carbon-Carbon Double Bonds
Synthesis of Double Bonds of Defined Stereochemistry
Stereo-Controlled Vinyl Anion Equivalents
Electrophilic Attack on Alkenes
Vinyl Cations: Palladium-Catalysed C-C Coupling
Allyl Alcohols: Allyl Cation Equivalents (and More)
Stereochemistry
Control of Stereochemistry - Introduction
Controlling Relative Stereochemistry
Resolution
The Chiral Pool
Asymmetric Induction I: Reagent-Based Strategy
Asymmetric Induction II: Asymmetric Catalysis: Formation of C-O and C-N Bonds
Asymmetric Induction III: Asymmetric Catalysis: Formation of C-H and C-C Bonds
Asymmetric Induction IV: Substrate-Based Strategy
Kinetic Resolution
Enzymes: Biological Methods in Asymmetric Synthesis
New Chiral Centres from Old - Enantiomerically Pure Compounds & Sophisticated Syntheses
Strategy of Asymmetric Synthesis
Functional Group Strategy
Functionalisation of Pyridine
Oxidation of Aromatic Compounds, Enols and Enolates
Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements
Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms
Tandem Organic Reactions
General References
Index
Table of Contents provided by Publisher. All Rights Reserved.

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