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Summary

Regular practice makes perfect - and this is equally true of organic synthesis. Only the numerous and constantly new little tricks and tips make for elegant synthesis. Knowledge of synthesis methods, reactivities, reagents, protective groups and much more is best acquired - and retained - by way of detailed analysis and processing of complex synthesis paths. This workbook allows students to easily test and strengthen their own chemical repertoire by way of sixteen new syntheses, including tricycles, macrolides, terpenes, and alkaloids. It follows the tried-and-tested concept used in the first volume, although each volume can be read independently of the other. It briefly describes all the target molecules and the relevant synthesis tasks, before going on to classify them into smaller sub-problems that may be solved by the reader using tips given in varying detail. In this way, readers can define the degree of difficulty for themselves. The solution section with comments and a comprehensive discussion of the key steps in reaction sequences and their actual application allows a simple check of the student's own strategy. An appendix with references to original syntheses and further literature rounds off the whole. Whether prior to an examination, for preparing seminars or for ideas in looking for synthesis strategies, every organic chemist - practicing and ongoing - will profit from reading this workbook.

Author Biography

Christian Bittner and Anke S. Busemann are the authors of Organic Synthesis Workbook II, published by Wiley.

Table of Contents

Chapter 1. (+)-Asteriscanolide (Paquette 2000).
Chapter 2. (-)-Bafilomycin A1 (Roush 1999).
Chapter 3. Curacin A (Wipf 1996).
Chapter 4. Dysidiolide (Corey 1997).
Chapter 5. Efavirenz (Merck, DuPont 1999).
Chapter 6. (+)-Himbacine (Chackalamannil 1999).
Chapter 7. Hirsutine (Tietze 1999).
Chapter 8. (+)-Irinotecan(r) (Curran 1998).
Chapter 9. (+)-Laurallene (Crimmins 2000).
Chapter 10. Myxalamide A (Heathcock 1999).
Chapter 11. (+)-Paniculatine (Sha 1999).
Chapter 12. (+)-Polyoxin J (Gosh 1999).
Chapter 13. (-)-Scopadulcic Acid (Overman 1999).
Chapter 14. Sildenafil (VIAGRATM) (Pfizer 1998).
Chapter 15. GM2 (Schmidt 1997).
Chapter 16. H-Type II Tetrasaccharide Glycal (Danishefsky 1995).
Abbreviations.
Index

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