Written and edited by internationally recognized leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer.

Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment.

A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care.

The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

David J. Kerr, Professor of Cancer Medicine, Nuffield Division of Clinical and Laboratory Sciences, University of Oxford, UK,Daniel G. Haller, Professor Emeritus, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA,Cornelius J. H. van de Velde, Professor of Surgery and Head, Department of Surgical Oncology, Leiden University Medical Center, The Netherlands,Michael Baumann, Professor and Chair, Department of Radiation Oncology; Director, University Cancer Center; and Coordinator, German Cancer Consortium (DKTK), Medical Faculty and University Hospital Carl Gustav Carus, Technical University of Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Germany; German Cancer Consortium (DKTK) partner site, Dresden, Germany; and German Cancer Center (DKFZ) Heidelberg, Germany,Nagahiro Saijo, Professor, Kinki University School of Medicine; Member of Executive Advisory Board, West Japan Oncology Group; and Deputy Director of the National Cancer Center Hospital East,

David Kerr has made a sustained and internationally recognised contribution to cancer care and research in the field of medical oncology over the past three decades. He has published over 400 papers in high profile journals, authored over twenty books and has been awarded four prestigious, international research prizes, including the NHS's first Nye Bevan award for Innovation. His scientific standing has been recognised by election as Fellow of the Royal College of Physicians, Fellow of Academy of Medical Sciences, President of the European society of Medical Oncology (2009-2011) and Founding Fellow of the European Academy of Cancer Sciences.

Section 1: Hallmarks of Cancer
1. The hallmarks of cancer, Douglas Hanahan and Robert A. Weinberg
2. Growth factors and uncontrolled proliferation, Shujuan Liu and Ahmed Ashour Ahmed
3. Cell signalling pathways, Stefan Knapp
4. Cell cycle control, Simon Carr and Nicholas La Thangue
5. Cancer cell death, Amanda S. Coutts, Sandra Maniam, and Nicholas La Thangue
6. Angiogenesis, Yull E. Arriaga and Arthur E. Frankel
7. Invasion and metastases, Andrew P. Mazar, Andrey Ugolkov, Jack Henkin, Richard Ahn, and Thomas V. O'Halloran
8. Genetic instability, Sir Walter Bodmer and Jenny Wilding
9. DNA repair after oncological therapy, E. Dikomey, K. Borgmann, M. Kriegs, W. Mansour, C. Petersen, and T. Rieckmann
10. Biology of cancer stem cells, Andreas Trumpp
11. Biomarker identification and clinical validation, Richard D Kennedy, Manuel Salto-Tellez, D. Paul Harkin, and Patrick G Johnston
12. Cancer, immunity, and inflammation, Campbell SD Roxburgh and Donald C McMillan
13. Cancer and metabolism, Cameron Snell, Kevin C Gatter, Adrian L Harris, Francesco Pezzella
Section 2: Etiology and Epidemiology of Cancer
14. Smoking and cancer, Jonathan Samet
15. Viruses, Chris Boshoff
16. Chemical carcinogens, Paula A. Oliveira
17. Radiation, Klaus Trott
18. Body fatness, physical activity, diet, and other lifestyle factors, Ellen Kampman and Franzel van Duijnhoven
Section 3: Principles of Oncology
19. Practice points for surgical oncology, PG Boelens, CBM van den Broek, and CJH van de Velde
20. Practice points for radiation oncology, Annekatrin Singer, Stephanie E. Combs, Jurgen Debus, and Michael Baumann
21. Principles of chemotherapy, David Kerr, Daniel Haller, and Jaap Verweij
22. Delivery of multidisciplinary cancer care, David N Church, Rachel S Midgley, and David J Kerr
23. Principles of clinical pharmacology: Introduction to pharmacokinetics and pharmacodynamics, Michael Ong and Udai Banerji
24. Design and analysis of clinical trials, Dan Sargeant and Qian Shi
25. Medical ethics in oncology, Eric A. Singer
26. Health economic assessment of cancer therapy, Jeffrey Peppercorn
Section 4: Population Health
27. Cancer control: The role of national plans, Masoud Samiei
28. Cancer prevention: Vaccination, Sarah Goltz and Julian Lob-Levyt
29. Cancer prevention: Chemoprevention, Hans-Joerg Senn, Nadir Arber, and Dirk Schrijvers
30. Population cancer screening, Andrew Evans, Simon Herrington, and Robert Steele
31. Familial cancer syndromes and genetic counselling, Henry T. Lynch, Carrie L. Snyder, and Jane F. Lynch (deceased)
Section 5: Support for the cancer patient
32. Supportive palliative care, David Hui and Eduardo Bruera
33. Quality of life, Neil Aaronson and Peter Fayers
34. Cancer survivorship and rehabilitation, Rachel L. Yung and Ann H. Partridge
Section 6: Disease
35. Cancer of the head and neck, Christine Chung, Andreas Dietz, Vincent Gregoire, Marco Guzzo, Marc Hamoir, Rene Leemans, Jean-Louis Lefebvre, Lisa Licitra, Adel El-Naggar, Brian O?Sullivan, Bing Tan, Vincent Vandecaveye, Vincent Vander Poorten, Jan Vermorken, and Michelle Williams
36. Oesophageal cancer, Eric Van Cutsem, Christophe M. Deroose, Piet Dirix, Karin Haustermans, Tony Lerut, Philippe Nafteux, Hans Prenen, and Xavier Sagaert
37. Gastric cancer, Hideaki Bando, Takahiro Kinoshita, Yasutoshi Kuboki, Atsushi Ohtsu, and Kohei Shitara
38. Rectal cancer, Regina Beets-Tan, Bengt Glimelius, and Lars Pahlman
39. Colon cancer, John Zalcberg, Stephen Fox, Alexander Heriot, Jon Knowles, Sam Ngan, Michael Michael, Kathryn Field, and Iris Nagtegaal
40. Pancreatic cancer, J. Weitz, M.W. Buchler, Paul D Sykes, John P Neoptolemos, Eithne Costello, Christopher M Halloran, Frank Bergmann, Peter Schirmacher, Ulrich Bork, Stefan Fritz, Jens Werner, Thomas Brunner, Elizabeth Smyth, David Cunningham, Brian R. Untch, and Peter J. Allen
41. Hepatobiliary cancer, Graeme J Poston, Nicholas Stern, Jonathan Evans, Priya Healey, Daniel Palmer, and Mohandas K. Mallath
42. Peritoneal mesothelioma, H. Richard Alexander, Jr., Dario Baratti, Terence C. Chua, Marcello Deraco, Raffit Hassan, Marzia Pennati, Federica Perrone, Paul H. Sugarbaker, Anish Thomas, Keli Turner, Tristan D. Yan and Nadia Zaffaroni
43. Cancer of the breast, Martine Piccart, Toral Gathani, Dimitrios Zardavas, Hatem A. Azim Jr., Christos Sotiriou, Giuseppe Viale, Emiel J T Rutgers, Mechthild Krause, Monica Arnedos, Suzette Delaloge, Fabrice Andre, and Felipe Ades
44. Gynaecological cancers, Richard Potter, Shujuan Liu, Bolin Liu, Sebastien Gouy, Sigurd Lax, Eric Leblanc, Philippe Morice, Fabrice Narducci, Alexander Reinthaller, Maximilian P Schmid, Catherine Uzan, and Pauline Wimberger
45. Genitourinary cancer, John Fitzpatrick, Asif Muneer , Jean de la Rosette, and Thomas Powles
46. Lung cancer, Rafal Dziadziuszko, Michael Baumann, Tetsuya Mitsudomi, Keith M. Kerr, Solange Peters, and Stefan Zimmermann
47. Neoplasms of the thymus, Rebecca Butof, Axel Denz, Gustavo Baretton, Jan Stohlmacher-Williams, and Michael Baumann
48. Pleural mesothelioma, Andrea S. Wolf, Assunta De Rienzo, Raphael Bueno, Lucian R. Chirieac, Joseph Corson, Elizabeth H. Baldini, David Jackman, Ritu Gill, Walter Weder, Isabelle Opitz, Ann S. Adams, and David J. Sugarbaker
49. Skin cancer: melanoma, John F Thompson, Richard A Scolyer, and Richard F Kefford
50. Skin cancer: non-melonoma, Diona L. Damian, Richard A. Scolyer, Graham Stevens, Alexander Menzies, and John F. Thompson
51. Acute leukemia, Adele K. Fielding, Charles G. Mullighan, Dieter Hoelzer, Eytan M. Stein, Ghada Zakout, Martin S. Tallman, Ross Levine, Yishai Ofran, Jacob M. Rowe, and Ross L. Levine
52. Chronic leukemias, Hemant Malhotra, Lalit Kumar, Pankaj Malhotra, Devendra Hiwase, and Ravi Bhatia
53. Myeloma, Charlotte Pawlyn, Faith Davies, and Gareth Morgan
54. Lymphomas, Frank Kroschinsky, Friedrich Stolzel, Stefano A. Pileri, Bjoern Chapuy, Rainer Ordemann, Christian Gisselbrecht, Tim Illidge, David C. Hodgson, Mary K. Gospodarowicz, Christina Schutze, and Gerald Wulf
55. Sarcomas of the soft tissue, Alessandro Gronchi, Angelo P. Dei Tos, and Paolo G. Casali
56. Cancer of the central nervous system, Puneet Plaha, Allyson Parry, Pieter Pretorius, Michael Brada, Olaf Ansorge, and Claire Blessing
57. Cancer of the eye and orbit, Daniel G. Ezra, Geoffrey E. Rose, Jacob Pe'er, Sarah Coupland, S. Seregard, G.P.M. Luyten, and Annette C. Moll
58. Endocrine cancers, David Kerr, Andrew Weaver, Anthony P. Weetman, Oliver Gimm, Ashley Grossman, Petra Sulentic, Bertram Wiedenmann, Ulrich-Frank Pape, John Wass, Angela Rogers, and W de Herder
59. Cancer of unknown primary site, Nicholas Pavlidis and George Pentheroudakis
Index