The pace of change in transfusion medicine is relentless with new scientific and technological developments, and continuing efforts to improve transfusion practice. The sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017.

The primary purpose of this edition remains the same as the first, namely, to provide a comprehensive guide to transfusion medicine. The book aims to include information in more depth than contained within handbooks of transfusion medicine, and yet to present that information in a more concise and approachable manner than seen in standard reference texts. The sixth edition is a standalone text which will be useful to the many clinical and scientific staff, not only for trainees, who require an overview of the field, but also for established practitioners who areinvolved in some aspect of transfusion medicine and require an accessible reference book.

Systematically taking the reader through the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals, clinical transfusion practice, a new section on patient blood management, cellular and tissue therapy and organ transplantation and the development of the evidence base for transfusion, Practical Transfusion Medicine remains the foremost textbook on the subject. Featuring a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding, the sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine.

Michael F. Murphy is Professor of Transfusion Medicine at the University of Oxford, and Consultant Haematologist for NHS Blood & Transplant and the Department of Haematology, Oxford University Hospitals NHS Foundation Trust

David J. Roberts is Professor Haematology at University of Oxford, Medical Director for Pathology for NHS Blood and Transplant and also works as a Consultant Haematologist in the Department of Haematology, John Radcliffe Hospital, Oxford.

Mark H. Yazer is a Professor of Pathology at the University of Pittsburgh, an Adjunct Professor of Clinical Immunology at the University of Southern Denmark, and a Visiting Professor of Pathology at Tel Aviv University. His research interest is in blood use in massive bleeding.

Nancy M. Dunbar is an Associate Professor of Pathology and Laboratory Medicine at the Geisel School of Medicine at Dartmouth and serves as the Medical Director of the Blood Bank at Dartmouth-Hitchcock Medical Center.

List of contributors

Preface to the sixth edition

1 Introduction: Two centuries of progress in transfusion medicine
Walter H. (Sunny) Dzik and Michael F. Murphy

Part I Basic Principles of Immunohaematology

2 Essential immunology for transfusion medicine
Gregory A. Denomme

3 Human blood group systems
Geoff Daniels and Sean Stowell

4 Human leukocyte antigens
Harold C. Sullivan and Caroline R. Alquist

5 Platelet and neutrophil antigens
Brian R. Curtis

6 Pretransfusion testing and the selection of red cell products for transfusion
Mark H. Yazer, Meghan Delaney and Gregory A. Denomme

Part II Complications of Transfusions

7 Investigation of acute transfusion reactions
Heather Leary, Kathryn E. Webert and Nancy M. Heddle

8 Haemolytic transfusion reactions
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman

9 Febrile and allergic transfusion reactions
Sarah K. Harm and Mark K. Fung

10 Tranfusion-associated circulatory overload
Robert B. Klanderman and Alexander P.J. Vlaar

11 Transfusion-related acute lung injury (TRALI)
Alexander P.J. Vlaar and Rick Kapur

12 Purported adverse effects of ‘old blood’
Lirong Qu and Darrell J. Triulzi

13 Transfusion-induced immunomodulation
Neil Blumberg, Majed A. Refaai and Joanna M. Heal

14 Transfusion-associated graft-versus-host disease and microchimerism
Alexandra Budhai, Richard O. Francis and Beth H. Shaz

15 Posttransfusion purpura
Michael F. Murphy

16 Heparin-induced thrombocytopenia
Theodore E. Warkentin and Andreas Greinacher

17 Transfusion-transmitted infections
Steven J. Drews and Roger Y. Dodd

18 Bacterial contamination
Sandra Ramírez-Arcos and Mindy Goldman

19 Emerging infections and transfusion safety
Roger Y. Dodd

Part III Practice in Blood Centres and Hospitals

20 Regulatory aspects of blood transfusion
William G. Murphy, Louis M. Katz and Peter Flanagan

21 The role of hemovigilance in transfusion safety
Katharine A. Downes and Barbee I. Whitaker

22 Donors and blood collection
Marc Germain and Pierre Tiberghien

23 Blood donation testing and the safety of the blood supply
Mindy Goldman and Steven J. Drews

24 Production and storage of blood components
Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo

25 Blood transfusion in hospitals
Zoe K. McQuilten, Erica M. Wood, Mark H. Yazer and Michael F. Murphy

26 Disaster preparedness
Heidi Doughty, Fateha Chowdhury and Richard Rackham

27 Blood transfusion in a global context
David J. Roberts, Imelda Bates, Stephen P. Field, Aggrey Dhabangi, Jean Pierre Allain and Meghan Delaney

Part IV Clinical Transfusion Practice

28 Inherited and acquired disorders of haemostasis
Irina Chibisov, Jansen Seheult and Franklin Bontempo

29 Point-of-care haemostasis testing
Katrina M. Morgan, Matthew D. Neal, Louis Alarcon and Christine M. Leeper

30 Transfusion in bleeding patients
Aaron S. Hess, Lynn G. Stansbury and John R. Hess

31 Transfusion in non-bleeding medical and surgical patients
Killian Donovan, Akshay Shah, Stuart McKechnie and Simon Stanworth

32 Transfusion in malignant haematological disease
Lise J. Estcourt and Michael F. Murphy

33 Transfusion in benign haematological disease
Eric Salazar and Christopher A. Tormey

34 Transfusion in patients with haemoglobinopathies
Yvette Tanhehco and Patricia A. Shi

35 Transfusing neonates and infants
Marianne E. Yee and Cassandra D. Josephson

36 Immunodeficiency and immunoglobulin therapy
Siraj A. Misbah

Part V Patient Blood Management

37 Development of a patient blood management programme
Jonathan H. Waters

38 Perioperative patient blood management
Martin Shao Foong Chong, Martin Rooms, Ravishankar Rao Baikady and Toby Richards

39 Restrictive transfusion practice and how to implement it
Marie A. Hollenhorst and Lawrence Tim Goodnough

40 Using data to support patient blood management
Nadia B. Hensley, Sandaruwani Abeysiri and Steven M. Frank

Part VI Cellular Therapy and Transplantation

41 Regulation and accreditation in cellular therapy
Julia Wolf, Zbigniew (Ziggy) M. Szczepiorkowski and James Griffin

42 Stem cell collection and therapeutic apheresis
Khaled El-Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski

43 Haemopoietic stem cell processing and storage
Akash Gupta and Ronan Foley

44 Haematopoietic cell transplantation
Richard Salisbury, Yisu Gu, Rachael Hough and Robert D. Danby

45 CAR-T cells and recent advances in clinical cellular immunotherapy
Yisu Gu, Alex Rampotas, Connor Sweeney, David J. Roberts and Ronjon Chakraverty

46 Tissue banking
Akila Chandrasekar, Richard Lomas and Paul Rooney

Part VII Development of the Evidence Base for Transfusion

47 Observational and interventional trials in transfusion medicine
Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert

48 Getting the most out of the evidence for transfusion medicine and lessons from the COVID-19 pandemic
Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Yulia Lin

49 A primer on biostatistics
Andrew W. Shih, Na Li, Celina Montemayor and Nancy M. Heddle

50 A primer on health economics
Seema Kacker and Aaron A.R. Tobian

51 Scanning the future of transfusion medicine
Jay E. Menitove, Paul M. Ness, Suzanne R. Thibodeaux and Edward L. Snyder

Index