Contributing Authors |
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xi | (6) |
The American Society for Bone and Mineral Research |
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xvii | (2) |
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Preface to the First Edition |
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xix | (2) |
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Preface to the Third Edition |
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xxi | (2) |
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Acknowledgments |
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xxiii | |
Section I. Anatomy and Biology of Bone Matrix and Cellular Elements |
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3 | (38) |
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1. Anatomy and Ultrastructure of Bone |
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3 | (8) |
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2. Osteoblast Cell Biology -- Lineage and Functions |
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11 | (5) |
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16 | (8) |
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4. Bone Matrix Proteins and the Mineralization Process |
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24 | (5) |
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5. Regulation of Bone Remodeling |
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29 | (6) |
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6. The Osteoblast Lineage--Embryologic Origins and the Differentiation Sequence |
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35 | (6) |
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Section II. Calcium, Magnesium, Phosphorus Homeostasis and Physiology, and Biochemistry of Calcium Regulating Hormones |
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41 | (50) |
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7. Calcium, Magnesium and Phosphorus: Intestinal Absorption |
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41 | (8) |
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8. Calcium, Magnesium and Phosphorus: Renal Handling and Urinary Excretion |
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49 | (8) |
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9. Mineral Balance and Homeostasis |
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57 | (6) |
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10. Synthesis, Circulating Heterogeneity, and Metabolism of Parathyroid Hormone |
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63 | (5) |
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11. Parathyroid Hormone: Mechanism of Action |
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68 | (3) |
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12. Parathyroid-Hormone-Related Protein |
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71 | (3) |
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13. Vitamin D: Photobiology, Metabolism, Mechanism of Action and Clinical Applications |
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74 | (8) |
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82 | (9) |
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Section III. Clinical Evaluation of Bone and Mineral Disorders |
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91 | (86) |
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15. History and Physical Examination |
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91 | (2) |
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16. Blood, Calcium, Phosphorus, and Magnesium |
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93 | (3) |
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17. Parathyroid Hormone and Calcitonin |
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96 | (9) |
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18. Parathyroid-Hormone-Related Protein Assays |
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105 | (4) |
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19. Vitamin D Metabolites |
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109 | (5) |
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20. Biochemical Markers of Bone Turnover |
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114 | (5) |
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21. Radiologic Evaluation of Bone Mineral in Children |
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119 | (15) |
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22. Scintigraphy in Metabolic Bone Disease |
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134 | (8) |
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23. Bone Density Measurement and the Management of Osteoporosis |
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142 | (10) |
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24. Radiology of Osteoporosis and Other Metabolic Bone Diseases |
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152 | (13) |
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25. Bone Biopsy and Histomorphometry in Clinical Practice |
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165 | (3) |
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26. Molecular Diagnosis of Bone and Mineral Disorders |
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168 | (9) |
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Section IV. Disorders of Serum Minerals |
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177 | (71) |
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27. Hypercalcemia: Pathogenesis, Clinical Manifestations, Differential Diagnosis, and Management |
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177 | (4) |
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28. Primary Hyperparathyroidism |
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181 | (6) |
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29. Familial Hyperparathyroid Syndromes |
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187 | (3) |
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30. Familial Hypocalciuric Hypercalcemia |
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190 | (2) |
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31. Tertiary Hyperparathyroidism and Refractory Secondary Hyperparathyroidism |
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192 | (6) |
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32. Humoral Hypercalcemia of Malignancy |
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198 | (5) |
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33. Hypercalcemia in Hematologic Malignancies and in Solid Tumors Associated with Extensive Localized Bone Destruction |
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203 | (3) |
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34. Hypercalcemia Due to Granuloma-Forming Disorders |
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206 | (3) |
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35. Hypercalcemic Syndromes in Infants and Children |
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209 | (4) |
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36. Miscellaneous Causes of Hypercalcemia |
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213 | (4) |
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37. Hypocalcemia: Pathogenesis, Differential Diagnosis, and Management |
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217 | (3) |
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220 | (3) |
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39. Parathyroid Hormone Resistance Syndromes |
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223 | (5) |
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40. Neonatal Hypocalcemia |
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228 | (2) |
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41. Miscellaneous Causes of Hypocalcemia |
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230 | (4) |
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42. Magnesium Depletion and Hypermagnesemia |
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234 | (4) |
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43. Hyperphosphatemia and Hypophosphatemia |
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238 | (10) |
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Section V. Metabolic Bone Diseases |
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248 | (114) |
Section V. Introduction |
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248 | (1) |
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44. Epidemiology of Osteoporosis |
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249 | (4) |
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45. Pathogenesis of Postmenopausal Osteoporosis |
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253 | (1) |
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46. Physical Activity and Regulation of Bone Mass |
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254 | (2) |
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47. Prevention of Osteoporosis |
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256 | (6) |
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48. Nutrition and Osteoporosis |
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262 | (2) |
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49. Evaluation and Treatment of Postmenopausal Osteoporosis |
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264 | (8) |
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50. The Special Problem of Hip Fracture |
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272 | (3) |
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51. Juvenile Osteoporosis |
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275 | (3) |
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52. Glucocorticoid and Drug-Induced Osteoporosis |
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278 | (5) |
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283 | (3) |
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54. Hyperthryoidism, Thyroid Hormone Replacement, and Osteoporosis |
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286 | (3) |
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55. Miscellaneous Causes of Osteoporosis |
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289 | (4) |
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56. Orthopeidc Complications of Osteoporosis |
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293 | (6) |
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57. Osteoporosis and Rheumatic Diseases |
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299 | (2) |
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58. Nutritional Rickets and Osteomalacia |
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301 | (5) |
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59. Metabolic Bone Disease in Gastrointestinal, Hepatobiliary, and Pancreatic Disorders |
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306 | (5) |
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60. Vitamin D-Dependent Rickets |
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311 | (5) |
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61. Hypophosphatemic Vitamin D-Resistant Rickets |
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316 | (3) |
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62. Tumor-Induced Rickets and Osteomalacia |
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319 | (7) |
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326 | (2) |
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64. Fanconi Syndrome and Renal Tubular Acidosis |
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328 | (5) |
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65. Drug-Induced Osteomalacia |
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333 | (4) |
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66. Metabolic Bone Disease of Total Parenteral Nutrition |
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337 | (4) |
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67. Renal Osteodystrophy in Adults and Children |
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341 | (21) |
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Section VI. Genetic, Developmental, and Dysplastic Skeletal Disorders |
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362 | (28) |
Section VI. Introduction |
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362 | (1) |
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68. Sclerosing Bone Dysplasias |
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363 | (17) |
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380 | (2) |
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70. Osteogenesis Imperfecta |
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382 | (3) |
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71. Chondrodystrophies and Mucopolysaccharidoses |
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385 | (5) |
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Section VII. Acquired Disorders of Cartilage and Bone |
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390 | (19) |
Section VII. Introduction |
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390 | (1) |
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391 | (8) |
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73. Ischemic Bone Disease |
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399 | (4) |
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74. Infiltrative Disorders of Bone |
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403 | (6) |
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Section VIII. Paget's Disease |
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409 | (13) |
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75. Paget's Disease of Bone |
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409 | (13) |
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Section IX. Extraskeletal (Ectopic) Calcification and Ossification |
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422 | (10) |
Section IX. Introduction |
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422 | (2) |
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424 | (2) |
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426 | (2) |
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78. Fibrodysplasia (Myositis) Ossificans Progressive |
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428 | (4) |
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Section X. Nephrolithiasis |
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432 | (15) |
Section X. Introduction |
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432 | (1) |
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433 | (5) |
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80. Urologic Aspects of Nephrolithiasis Management |
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438 | (9) |
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Section XI. Appendix |
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447 | (20) |
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i. Growth Charts for Males and Females |
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447 | (2) |
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449 | (2) |
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iii. Laboratory Values of Importance for Calcium Metabolism and Metabolic Bone Disease |
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451 | (2) |
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iv. Mineral and Vitamin D RDAs for Infants, Children, and Adults |
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453 | (1) |
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v. Formulary of Drugs Commonly Used in Treatment of Mineral Disorders |
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454 | (4) |
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vi. Structure of Naturally Occurring Vitamin D and Synthetic Analogs |
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458 | (1) |
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459 | (4) |
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viii. Bone Density Reference Data |
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463 | (4) |
Subject Index |
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467 | |