Redox Signaling and Regulation in Biology and Medicine

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Edition: 1st
Format: Hardcover
Pub. Date: 2009-06-08
Publisher(s): Wiley-VCH
List Price: $165.33

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Summary

This first entry'level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Author Biography

Claus Jacob is the head of the department of Bioinorganic Chemistry at Saarland University (Germany). Professor Jacob studied Chemistry at the Universities of Leicester and Oxford (UK) and received his PhD in bioinorganic chemistry from Oxford University in 1997. Since then, he has also been researching and lecturing at the Heinrich Heine Universit+ñt in D++sseldorf (Germany), the University of Exeter (UK) and the University of Metz (France).

Paul Winyard is a Professor of Experimental Medicine at the Universities of Exeter and Plymouth (UK). After his studies in Biochemistry at the Universities of Gothenburg (Sweden) and Wales (UK), he obtained his PhD in Medicine from the University of Birmingham (UK) in 1987. Between 1988 and 2001 he was Lecturer and Reader at Queen Mary University (London) and the London Hospital Medical College. He also spent one year as a visiting Professor at the University of California in San Francisco (USA).

Table of Contents

Introduction
Biological Systems Relevant for Redox Signaling and Control
Cellular Generation of Oxidants: Relation to Oxidative Stress
The Chemical Basis of Biological Redox Control
Protein Glutathiolation
Structure and Function of the Human Peroxiredoxin-Based Antioxidant System: the Interplay between Peroxiredoxins, Thioredoxins, Thioredoxin Reductases, Sulfiredoxins and Sestrins
Hydrogen Peroxide and Cysteine Protein Signaling Pathways
Protein Tyrosine Phosphatases as Mediators of Redox Signaling
Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1a
Eicosanoid-Based Signaling
Redox-Controlled Transcription Factors and Gene Expression
Nitric Oxide Regulation in Redox Signaling
Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature?
Aspects of Nox/Duox Signaling
Photodynamic Therapy with Aminolevulinic Acid and Iron Chelators: A Clinical Example of Redox Signaling
Oxidative Stress and Apoptosis
Redox Regulation of Apoptosis in Immune Cells
Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin-Based Antioxidant System
Free Radicals and Mammalian Aging
Table of Contents provided by Publisher. All Rights Reserved.

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