Microencapsulation: Methods and Industrial Applications, Second Edition,9780824723170

Microencapsulation: Methods and Industrial Applications, Second Edition

by ;
Edition: 2nd
ISBN13: 9780824723170
ISBN10: 0824723171
Format: Hardcover
Pub. Date: 2005-11-01
Publisher(s): CRC Press
List Price: $230.00

Buy New

Usually Ships in 5-7 Business Days
$229.77
Add to Cart

Rent Textbook

Select for Price
Add to Cart
There was a problem. Please try again later.

Digital

Rent Digital Options
Online:180 Days access
Downloadable:180 Days
$201.30
Online:365 Days access
Downloadable:365 Days
$237.90
Online:1825 Days access
Downloadable:Lifetime Access
$366.00
*To support the delivery of the digital material to you, a non-refundable digital delivery fee of $3.99 will be charged on each digital item.
$201.30*
Add to Cart

Used Textbook

We're Sorry
Sold Out

Buy from our Marketplace starting at $164.95

How Marketplace Works:

  • This item is offered by an independent seller and not shipped from our warehouse
  • Item details like edition and cover design may differ from our description; see seller's comments before ordering.
  • Sellers much confirm and ship within two business days; otherwise, the order will be cancelled and refunded.
  • Marketplace purchases cannot be returned to eCampus.com. Contact the seller directly for inquiries; if no response within two days, contact customer service.
  • Additional shipping costs apply to Marketplace purchases. Review shipping costs at checkout.

Summary

Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides practical approaches to complex formulation problems encountered in the development of particulate delivery systems at the micro- and nano-size level. Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.

Table of Contents

Preface to the Second Edition iii
Preface to the First Edition v
Contributors xv
PART I: METHODS OF ENCAPSULATION AND ADVANCES IN PRODUCTION TECHNOLOGY
Biodegradable Microspheres: Advances in Production Technology
1(54)
Frederic Tewes
Frank Boury
Jean-Pierre Benoit
Introduction
1(1)
Techniques Using Organic Solvents
2(6)
Techniques Without Organic Solvents
8(33)
References
41(14)
Advances in the Technology for Controlled-Release Pesticide Formulations
55(24)
Arie Markus
Charles Linder
Introduction
55(4)
Standard Microencapsulation Processes for Pesticides
59(8)
Advances in Encapsulation Technologies
67(4)
Quality Control
71(4)
Case Study: De-Bugger®
75(1)
Summary
75(1)
References
76(3)
Multiparticulate Pulsatile Drug Delivery Systems
79(20)
Till Bussemer
Roland Bodmeier
Introduction
79(4)
Pulsatile Systems
83(1)
Site-Specific Systems
84(2)
Time-Controlled Pulsatile Systems
86(1)
Multiparticulate Systems
87(7)
Outlook
94(1)
References
94(5)
Microencapsulation Techniques for Parenteral Depot Systems and Their Application in the Pharmaceutical Industry
99(24)
Thomas Kissel
Sascha Maretschek
Claudia Packhauser
Julia Schnieders
Nina Seidel
Introduction
99(1)
Biodegradable Polymers
100(3)
Phase Separation and Coacervation
103(3)
W/O/W-Double Emulsion Technique
106(7)
Spray Drying
113(5)
Conclusion
118(1)
References
118(5)
Coupling Methods to Obtain Ligand-Targeted Liposomes and Nanoparticles
123(26)
Leila Bossy-Nobs
Franz Buchegger
Robert Gurny
Eric Allemann
Introduction
123(1)
Liposomal Modification Techniques
124(14)
Labeling Polymeric Nanoparticles with Ligands
138(3)
How to Choose the Coupling Method
141(1)
Concluding Remarks
142(1)
References
142(7)
Industrial Technologies and Scale-Up
149(34)
Francois Puel
Stephanie Briancon
Hatem Fessi
Introduction
149(3)
Emulsification Processes
152(12)
Scale-Up Approach: The Case of Emulsification
164(3)
Applications---Examples
167(11)
Summary
178(1)
Notations
178(1)
References
179(4)
PART II: EVALUATION AND CHARACTERIZATION OF MICRO- AND NANOPARTICULATE DRUG DELIVERY SYSTEMS
Drug Release from Microparticulate Systems
183(30)
Shicheng Yang
Clive Washington
Introduction
183(1)
Measurement of Drug Release
183(3)
Mechanisms of Drug Release
186(2)
Drug Release Kinetic Models
188(10)
Empirical Models and Comparison of Drug Release Profiles
198(5)
In Vitro-In Vivo Correlation
203(1)
Summary
204(1)
References
205(8)
Manufacture, Characterization, and Applications of Solid Lipid Nanoparticles as Drug Delivery Systems
213(56)
Heike Bunjes
Britta Siekmann
Introduction: The Rationale of Using Biodegradable, Nanoparticulate Solid Lipids in Drug Delivery
213(3)
Manufacturing Methods for Lipid Nanoparticle Suspensions
216(14)
Physicochemical Characterization of Colloidal Lipid Suspensions and Nanoparticles
230(12)
Applications in Drug Delivery
242(13)
Conclusions
255(2)
References
257(12)
Amphiphilic Cyclodextrins and Microencapsulation
269(28)
Erem Memisoglu-Bilensoy
A. Atilla Hincal
Amelie Bochot
Laury Trichard
Dominique Duchene
Introduction
269(1)
Cyclodextrins and Derivatives
270(8)
Amphiphilic Cyclodextrin Nanoparticles
278(13)
Conclusion
291(1)
References
291(6)
Lipospheres for Controlled Delivery of Substances
297(20)
Abraham J. Domb
Introduction
297(1)
Preparation of Lipospheres
298(1)
Physical Characterization of Lipospheres
299(3)
Applications of Lipospheres
302(12)
Summary
314(1)
References
315(2)
Pharmaceutical Aspects of Liposomes: Academic and Industrial Research and Development
317(28)
Rimona Margalit
Noga Yerushalmi
Introduction
317(1)
Liposomes: Definition, Needs for, and Outline of their Advantages and Drawbacks
318(5)
Selection of the Liposome Type/Species: Views and Criteria from Academic and Industrial Research and Their Proposed Integration
323(3)
Targeted/Modified Liposomes: An Interesting and Exciting Scientific Tool, But Can They Be Made into Products (Especially Immunoliposomes)?
326(4)
Liposomes as a Sterile, Pyrogen-Free System with Pharmaceutically Acceptable Shelf-Life, Stability, and Dosage Forms
330(3)
Liposome Characteristics (Percentage of Encapsulation, Kinetics of Release, Biological Activity) In Basic Research and in Quality Assurance
333(7)
Summary and Prospects
340(1)
References
340(5)
Microemulsions for Solubilization and Delivery of Nutraceuticals and Drugs
345(84)
Nissim Garti
Abraham Aserin
The Rationale
345(3)
Microemulsions as Nanovehicles
348(1)
Part I---Microemulsion Preparation and Microstructures
349(36)
Part II---Potential Applications
385(29)
Final Remarks
414(2)
References
416(13)
PART III: APPLICATIONS OF PARTICULATE DELIVERY SYSTEMS
Self-Emulsifying Oral Lipid-Based Formulations for Improved Delivery of Lipophilic Drugs
429(52)
Jean-Sebastien Garrigue
Gregory Lambert
Simon Benita
Definition
429(1)
Introduction
430(1)
Drug Delivery Issues
430(3)
Composition of SEDDS
433(11)
Characterization of SEDDS
444(4)
Biopharmaceutical Aspects
448(18)
The Story of Oral Cyclosporin A
466(2)
The Oral Paclitaxel Challenge
468(1)
Future and Prospects
469(1)
References
470(11)
Recent Advances in Heparin Delivery
481(40)
Nathalie Ubrich
Philippe Maincent
Introduction
481(1)
Blood and Mechanism of Action of Heparins
482(1)
Evaluation of Heparin Efficiency
483(1)
Oral Delivery of Heparins
483(33)
Conclusion
516(1)
References
516(5)
Particulate Systems for Oral Drug Delivery
521(42)
Maria Jose Blanco-Prieto
Florence Delie
Introduction
521(1)
Absorption of Polymeric Particulates from the GI Tract
522(5)
Use of Polymeric Particles for Oral Administration
527(25)
Conclusions
552(1)
References
553(10)
Vesicles as a Tool for Dermal and Transdermal Delivery
563(24)
P. L. Honeywell-Nguyen
J. A. Bouwstra
Dermal and Transdermal Drug Delivery
563(1)
The Skin Barrier Function
564(2)
Vesicles as Skin Delivery Systems
566(6)
Elastic Vesicles
572(8)
References
580(7)
Lipid and Polymeric Colloidal Carriers for Ocular Drug Delivery
587(38)
Simon Benita
S. Tamilvanan
Introduction
587(2)
Topically Treated Ocular Pathologies
589(5)
Lipid and Polymeric Colloidal Carriers: Description and Classification
594(2)
O/W Submicron Emulsions
596(9)
Microemulsions
605(2)
Multiple Emulsions
607(1)
Nanoparticles
608(6)
Nanocapsules
614(3)
Future Directions in Ocular Drug Delivery Using Lipid and Polymeric Colloidal Carriers
617(1)
References
617(8)
The Use of Drug-Loaded Nanoparticles in Cancer Chemotherapy
625(48)
Jean-Christophe Leroux
Angelica Vargas
Eric Doelker
Robert Gurny
Florence Delie
Introduction
625(1)
In Vitro Uptake of NP by Tumoral Cells
626(13)
Distribution and Pharmacokinetics of Anticancer Drugs Coupled to NP
639(11)
In Vivo Activity and Toxicity of Anticancer Drugs Coupled to NP
650(11)
Concluding Remarks
661(1)
References
662(11)
Development of 5-FU-Loaded PLGA Microparticles for the Treatment of Glioblastoma
673(16)
Nathalie Faisant
Jean-Pierre Benoit
Philippe Menei
Introduction
673(1)
Microsphere Formulation and Development
674(4)
Preclinical Trials
678(4)
Application to Glioma Therapy After Tumor Resection: Phase I--II and IIB Studies
682(2)
Stereotaxic Implantation in Malignant Glioma: Phase I Study
684(1)
Conclusion
685(1)
References
686(3)
Nanoparticles as Drug Delivery Systems for the Brain
689(18)
Jorg Kreuter
Introduction
689(1)
Drug Delivery to the Brain with Nanoparticles
690(7)
Long Circulating Nanoparticles for Brain Drug Delivery
697(2)
Stability of Nanoparticles for Brain Delivery Upon Storage
699(1)
Mechanism of Nanoparticle-Mediated Drug Transport to the Brain
699(3)
Conclusions
702(1)
References
703(4)
Cosmetic Applications of Colloidal Delivery Systems
707(42)
Simon Benita
Marie-Claude Martini
Anne-Marie Orecchioni
Monique Seiller
Introduction
707(1)
Types of Vesicular Delivery Systems
708(7)
Composition
715(5)
Production
720(7)
Characterization
727(4)
Stability
731(1)
Cosmetic Uses
732(9)
Conclusion
741(1)
References
741(8)
Index 749

An electronic version of this book is available through VitalSource.

This book is viewable on PC, Mac, iPhone, iPad, iPod Touch, and most smartphones.

By purchasing, you will be able to view this book online, as well as download it, for the chosen number of days.

Digital License

You are licensing a digital product for a set duration. Durations are set forth in the product description, with "Lifetime" typically meaning five (5) years of online access and permanent download to a supported device. All licenses are non-transferable.

More details can be found here.

A downloadable version of this book is available through the eCampus Reader or compatible Adobe readers.

Applications are available on iOS, Android, PC, Mac, and Windows Mobile platforms.

Please view the compatibility matrix prior to purchase.